{"id":85926,"date":"2018-03-10T00:10:25","date_gmt":"2018-03-10T00:10:25","guid":{"rendered":""},"modified":"2018-03-10T00:10:25","modified_gmt":"2018-03-10T00:10:25","slug":"papel-de-las-celulas-linfomononucleares-en-la-regulacion-de-la-translocacion-bacteriana-la-produccion-de-tnf-alfa-y-la-expresion-de-la-nosi-hepatica-en-un-modelo-experimental-de-ictericia-obstructiv","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-las-celulas-linfomononucleares-en-la-regulacion-de-la-translocacion-bacteriana-la-produccion-de-tnf-alfa-y-la-expresion-de-la-nosi-hepatica-en-un-modelo-experimental-de-ictericia-obstructiv\/","title":{"rendered":"Papel de las celulas linfomononucleares en la regulacion de la translocacion bacteriana, la produccion de tnf-alfa y la expresion de la nosi hepatica, en un modelo experimental de ictericia obstructiva en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Octavio Frieyro Fernandez <\/strong><\/h2>\n<p>El tratamiento quirurgico de la ictericina obstructiva se asocia a una elevada morbimortalidad. Varios factores relacionados con la inmunosupresi\u00f3n podrian estar implicados en esta mayor tasa de complicaciones.  la traslocacion bacteriana y el aumento de la endotoxemia son dos hechos que se han demostrado, ocurren en etapas tempranas en modelos experimentales de ictericia obstructiva. En este sentido, se estudiaron estos dos fen\u00f3menos en relaci\u00f3n con la inmunodepresi\u00f3n observada, y el papel que en ello juegan los linfocitos t.  por otro lado, tanto la translocaci\u00f3n bacteriana, como la endotoxemia, estimulan la secreci\u00f3n, por parte de los macrofagos tisulares (cels. De kupffer en el tejido hepaticod), de varias citoquinas (entre ellas, el tnf-x), dando lugar a un estado proinflamatorio en la segunda parte de la tesis nos centramos en el oxido n\u00edtrico (no), molecula multifuncional implicada entre otras en la activaci\u00f3n leucocitaria y en diversos mecanismos de defensa antimicrobiana. En la sintes\u00eds de no estar implicada entre otras la no sintasa inducible (nosi), la cual requiere para su expresi\u00f3n la presencia de determinadas citoquinas. Entre los factores que regulan la expresi\u00f3n de la nosi, las celulas linfomononucleares juegan un papel fundamental.  al aparecer un estado pro-inflamatorio a nivel hepatico, en situaciones en ictericia obstructiva, se trat\u00f3 de relacionar la producci\u00f3n de no este nivel y el papel que en ello pudieran jugar las celulas linfomononucleares, observandose que la depresi\u00f3n linfocitaria que tiene lugar, favorece la expresi\u00f3n de la nosi, hecho en el que parece estar parcialmetne implicada una citoquina como es la il-4.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las celulas linfomononucleares en la regulacion de la translocacion bacteriana, la produccion de tnf-alfa y la expresion de la nosi hepatica, en un modelo experimental de ictericia obstructiva en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las celulas linfomononucleares en la regulacion de la translocacion bacteriana, la produccion de tnf-alfa y la expresion de la nosi hepatica, en un modelo experimental de ictericia obstructiva en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Octavio Frieyro Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Celdran Uriarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Martinez moreno <\/li>\n<li>Mar\u00eda  teresa Alberdi alonso (vocal)<\/li>\n<li>pedro Carda abella (vocal)<\/li>\n<li>jeronimo Farre muncharal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Octavio Frieyro Fernandez El tratamiento quirurgico de la ictericina obstructiva se asocia a una elevada morbimortalidad. Varios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,491,1737,139,2714],"tags":[56996,4988,180647,27338,180646,17603],"class_list":["post-85926","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-gastroenterologia","category-inmunologia","category-medicina-interna","category-vacunas","tag-angel-celdran-uriarte","tag-enrique-Martinez-moreno","tag-jeronimo-farre-muncharal","tag-maria-teresa-alberdi-alonso","tag-octavio-frieyro-fernandez","tag-pedro-carda-abella"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=85926"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/85926\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=85926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=85926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=85926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}