{"id":85949,"date":"2018-03-10T00:10:29","date_gmt":"2018-03-10T00:10:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-cistus-populifolius-sobre-musculo-liso-vascular\/"},"modified":"2018-03-10T00:10:29","modified_gmt":"2018-03-10T00:10:29","slug":"estudio-farmacologico-de-cistus-populifolius-sobre-musculo-liso-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-cistus-populifolius-sobre-musculo-liso-vascular\/","title":{"rendered":"Estudio farmacologico de cistus populifolius sobre musculo liso vascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Somoza Hernandez <\/strong><\/h2>\n<p>La especie cistus populofolius se utiliza en medicina popular como antiespasm\u00f3dico. se quer\u00eda conocer el principio activo dotado de propiedades relajantes de m\u00faculo liso vascular (mlv) y con posible efecto sobre la hipertensi\u00f3n arterial. Est\u00e1 se caracteriza por un aumento de las resistencias vasculares sit\u00e9micas, con el consiguiente incremento del tono vascular y cambios estructurales caracterizados por un incremento de la capa media vascular, lo cual conduce a un aumento de las c\u00e9lulas de mlv. Se lleg\u00f3 al aislamiento de la cumarina: esculetina y del heter\u00f3sido flav\u00f3nico: quercetol-3-gluc\u00f3sido. Es de sobra conocido el efecto de la quercetina sobre mlv,por lo que se centr\u00f3 el estudio farmacol\u00f3gico en la cumarina. A nivel de reactividad vascular se observ\u00f3 una vasodilataci\u00f3n a noradrenalina, que no parec\u00eda ser totalmente dependiente de la presencia de endotelio. Los estudios de proliferaci\u00f3n celular pusieron de manifiesto una disminuci\u00f3n en la s\u00edntesis de dna en c\u00e9lulas procedentes de ratas normotensas; y una remisi\u00f3n en la hipertrofia y poliploid\u00eda en c\u00e9lulas de ratas hipertensas. Los mecanismos de transducci\u00f3n implicados en esta se\u00f1al parecen ser la activaci\u00f3n de la guanilato ciclasa, con el consiguiente aumento en los niveles de gmpc y posterior activaci\u00f3n de la prote\u00ednquinasa gmpc-dependiente. Igualmente parece que la esculetina es capaz de activar la inos, aumentando los niveles de no, y por lo tanto, el mecanismo antiproliferativo sigue en parte la mima ruta que la del donante de no:snap.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de cistus populifolius sobre musculo liso vascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de cistus populifolius sobre musculo liso vascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Somoza Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Villar Del Fresno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>mercedes Salaices s\u00e1nchez (vocal)<\/li>\n<li>Jos\u00e9 Jim\u00e9nez mart\u00edn (vocal)<\/li>\n<li>benjam\u00edn Rodr\u00edguez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Somoza Hernandez La especie cistus populofolius se utiliza en medicina popular como antiespasm\u00f3dico. se quer\u00eda conocer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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