{"id":85969,"date":"2018-03-10T00:10:29","date_gmt":"2018-03-10T00:10:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-semivida-de-eliminacion-a-las-12-horas-postperfusion-del-metotrexato-a-dosis-altas-como-criterio-cla%c2%adnico-para-su-monitorizacion\/"},"modified":"2018-03-10T00:10:29","modified_gmt":"2018-03-10T00:10:29","slug":"la-semivida-de-eliminacion-a-las-12-horas-postperfusion-del-metotrexato-a-dosis-altas-como-criterio-cla%c2%adnico-para-su-monitorizacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-semivida-de-eliminacion-a-las-12-horas-postperfusion-del-metotrexato-a-dosis-altas-como-criterio-cla%c2%adnico-para-su-monitorizacion\/","title":{"rendered":"La semivida de eliminaci\u00f3n a las 12 horas postperfusi\u00f3n del metotrexato a dosis altas como criterio cl\u00ednico para su monitorizacion"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Concepcion Borras Almenar <\/strong><\/h2>\n<p>La toxicidad asociada al tratamiento del osteosarcoma con metotrexato a dosis altas es una circunstancia bien conocida aunque sujeta a una gran variabilidad por circunstancias inherentes al tratamiento o al estado fisiopatol\u00f3gico del paciente. En consecuencia, el establecimiento temprano de medidas que minimicen la yatrogenia del metotrexato (mtx) contribuye a reducir los riesgos para el paciente y se conforma, en consecuencia, como la alternativa terap\u00e9utica m\u00e1s eficiente.  en esta l\u00ednea se define un criterio para la valoraci\u00f3n del riesgo potencial de toxicidad por metotrexato en el tratamiento del osteosarcomay se plantean los siguientes objetivos:  1.-Determinar mediante el an\u00e1lisis de datos censurados, la influencia del factor de exposici\u00f3n y otros factores concurrentes, en la velocidad de presentaci\u00f3n de efectos adversos a metotrexato administrado a dosis altas.  2.- Analizar los criterios de exposici\u00f3n t12 y t24 como predictores de las diferencias en la respuesta farmacocin\u00e9tica del metotrexato en los pacientes.  3.- Desarrollar un modelo bayesiano a partir de un n\u00famero limitado de concentraciones plasm\u00e1ticas(10 min, 3h y 12 h postperfusi\u00f3n) de metotrexato y distintos factores de disposici\u00f3n de toxicidad en los pacientes capaz de predecir par\u00e1metros farmacocin\u00e9ticos individuales que garanticen concentraciones plasm\u00e1ticas de metotrexato seguras y eficaces.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La semivida de eliminaci\u00f3n a las 12 horas postperfusi\u00f3n del metotrexato a dosis altas como criterio cl\u00ednico para su monitorizacion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La semivida de eliminaci\u00f3n a las 12 horas postperfusi\u00f3n del metotrexato a dosis altas como criterio cl\u00ednico para su monitorizacion <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Concepcion Borras Almenar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Jimenez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andres Cervantes ruiperez <\/li>\n<li>carmen Mas arcas (vocal)<\/li>\n<li>eduardo Mari\u00f1o hernandez (vocal)<\/li>\n<li>virginia Merino sanJuan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Concepcion Borras Almenar La toxicidad asociada al tratamiento del osteosarcoma con metotrexato a dosis altas es una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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