{"id":86025,"date":"2018-03-10T00:10:33","date_gmt":"2018-03-10T00:10:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/comportamiento-farmacocinetico-del-mitoxantrone-en-la-poblacion-normal-y-con-metastasis-hepaticas\/"},"modified":"2018-03-10T00:10:33","modified_gmt":"2018-03-10T00:10:33","slug":"comportamiento-farmacocinetico-del-mitoxantrone-en-la-poblacion-normal-y-con-metastasis-hepaticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/comportamiento-farmacocinetico-del-mitoxantrone-en-la-poblacion-normal-y-con-metastasis-hepaticas\/","title":{"rendered":"Comportamiento farmacocin\u00e9tico del mitoxantrone en la poblaci\u00f3n normal y con met\u00e1stasis hep\u00e1ticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00c1lvaro Mar\u00eda Sanz Rubiales <\/strong><\/h2>\n<p>El mitoxantrone es una antracenodiona que se emplea como agente citost\u00e1tico en eltratamiento de tumores s\u00f3lidos como el c\u00e1ncer de mama, de vejiga y de pr\u00f3staa y en diversos tumores hemtol\u00f3gicos. Comparte con las antraciclinas la mayor parte de los efectos secundarios pero se diferencian en su poder cardiot\u00f3xico y en su capacidad para inducir alopecia, menor en el caso del mitoxantrone.Se ha estudiado la farmacocin\u00e9tica del mitoxantrone en 38 pacientes oncol\u00f3gicos, 17 de ellos con met\u00e1stasis hep\u00e1ticas.  para una dosis de  6mg\/m2 concentraci\u00f3n m\u00e1xima que se alcanza es de 0,78+952,86 l,un volumen del compratimiento central de 17,92 +13,76 l y un aclaramiento corporal total de 40,83 +14,42 l\/m\/h.  la semivida alfa es de 0,10+0,05 h, la semivida beta de 1,99+2,98 h y la semivida gamma de 13,34+6,49 h. Con estos datos hemos calculado un \u00e1rea bajo la curva abc de concentraci\u00f3n x tiempo de 0,16+0,07 mg*h\/l.  hemos encontrado una estabilizaci\u00f3n e incluso un discreto aumento transitorio en la concentraci\u00f3n plasm\u00e1tica de mitoxantrone a las 20-24 horas de su administraci\u00f3n que resulta compatible con un fen\u00f3meno de recirculaci\u00f3n enterohep\u00e1tica del f\u00e1rmaco.  en orina se ha podido recuperar una media del 7,7% delmitoxantrone administrado. se han encontrado correlaciones entre el \u00e1rea bajo la curva en el conjunto de la poblaci\u00f3n estudiada con el nivel de alb\u00famina, las cifras de ggt, got y gpt y, finalmente, con el \u00edndice de la masa corporal (peso\/talla2).  la presencia de met\u00e1stasis hep\u00e1ticas se asocia a unos niveles de concentraci\u00f3n plasm\u00e1tica m\u00e1s elevados y a un aumento del \u00e1rea bajo la curva. En estos pacientes tambi\u00e9n disminuye el aclarameinto corporal total y  se reducen el volumen parente de distribuci\u00f3n (vd) y el volumen del comportamiento central (vc).En los enfermos con met\u00e1stasis hep\u00e1ticas hay correlaci\u00f3n entre el \u00e1rea bajo la curva y nivel de alb\u00famina, la cifra de ggt y la edad.  se ha dise\u00f1ado y va<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Comportamiento farmacocin\u00e9tico del mitoxantrone en la poblaci\u00f3n normal y con met\u00e1stasis hep\u00e1ticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Comportamiento farmacocin\u00e9tico del mitoxantrone en la poblaci\u00f3n normal y con met\u00e1stasis hep\u00e1ticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00c1lvaro Mar\u00eda Sanz Rubiales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Buesa Perez Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Riera palmero <\/li>\n<li>Rafael Lopez lopez (vocal)<\/li>\n<li> Snatos miranda Juan  Antonio (vocal)<\/li>\n<li> Gonzalez san segundo M\u00aa del carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00c1lvaro Mar\u00eda Sanz Rubiales El mitoxantrone es una antracenodiona que se emplea como agente citost\u00e1tico en eltratamiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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