{"id":86056,"date":"2018-03-10T00:10:33","date_gmt":"2018-03-10T00:10:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificacion-molecular-de-ciclolignanos-antineoplasicos-selectivos\/"},"modified":"2018-03-10T00:10:33","modified_gmt":"2018-03-10T00:10:33","slug":"modificacion-molecular-de-ciclolignanos-antineoplasicos-selectivos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/modificacion-molecular-de-ciclolignanos-antineoplasicos-selectivos\/","title":{"rendered":"Modificacion molecular de ciclolignanos antineoplasicos selectivos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Anselmo Garc\u00eda Garc\u00eda <\/strong><\/h2>\n<p>El aldeh\u00eddo insaturado derivado de podofilotoxina, 9-oxo-   -apopicropodofilato de metilo, ha mostrado una importante citoxicidad selectiva para el carcinoma de colon humano ht-29, lo que ha dado lugar a la preparaci\u00f3n de an\u00e1logos ciclolign\u00e1nicos relacionados con \u00e9l que han sido evaluados frente a las l\u00edneas nepl\u00e1sicas p-388,a-549,ht-29 y mel-28.  primeramente se han hecho modificaciones en los anillos c y d de podofilotoxina, obteni\u00e9ndose derivados con diferente grado de oxidaci\u00f3n en las posiciones 7,9 y\/o 9, como son derivados carbon\u00f3licos, carbox\u00edlicos o con un grupo lactol.  por otra parte, se ha realizado la quimiomodulaci\u00f3n del aldeh\u00eddo cabeza de serie mediante reacciones de adici\u00f3n de diferentes nucle\u00f3filos carbonados y nitrogenados, as\u00ed como modificaciones en el anillo e del esqueleto ciclolign\u00e1nico. todas estas modificaciones han dado lugar a familias de compuestos con interesantes propiedades de cotoxicidad y selectividad.  cabe destacar los derivados im\u00ednicos por su selectividad importante frente a carcinoma de colon humano ht-29 y el grupo de metil lactonas. ambos presentan valores de ci 50 del mismo orden que los ciclolignanos trans-lact\u00f3nicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificacion molecular de ciclolignanos antineoplasicos selectivos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificacion molecular de ciclolignanos antineoplasicos selectivos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Anselmo Garc\u00eda Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo San Feliciano Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Plumet ortega <\/li>\n<li> Ayuso gonzalez M\u00aa Jos\u00e9 (vocal)<\/li>\n<li>Manuel Medarde agustin (vocal)<\/li>\n<li>Jos\u00e9 Carlos Menendez ramos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Anselmo Garc\u00eda Garc\u00eda El aldeh\u00eddo insaturado derivado de podofilotoxina, 9-oxo- -apopicropodofilato de metilo, ha mostrado una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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