{"id":86081,"date":"2018-03-10T00:10:38","date_gmt":"2018-03-10T00:10:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-farmacodinamia-de-ofloxacino-y-pefloxacino-en-profilaxis-de-cirugia-biliar\/"},"modified":"2018-03-10T00:10:38","modified_gmt":"2018-03-10T00:10:38","slug":"farmacocinetica-farmacodinamia-de-ofloxacino-y-pefloxacino-en-profilaxis-de-cirugia-biliar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-farmacodinamia-de-ofloxacino-y-pefloxacino-en-profilaxis-de-cirugia-biliar\/","title":{"rendered":"Farmacocinetica-farmacodinamia de ofloxacino y pefloxacino en profilaxis de cirugia biliar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eugenia Campo Cimarras <\/strong><\/h2>\n<p>El objetivo de la presente memoria experimental ha consistido en comprobar la eficacia de ofloxacino y pebloxacino como agentes profil\u00e1cticos en cirug\u00eda biliar en pacientes sometidos a colecistectom\u00eda, en funci\u00f3n de las concentraciones plasm\u00e1ticas y tisulares alcanzadas en los pacientes, asi como de los datos de sensibilidad de los principales patogenos del tracto biliar a estos agentes. Debido a que ofoxacino es un mezcla rac\u00e9mica de dos enanti\u00f3meros, s-(-)- y r-(+)-ofloxacino,y que uno de ellos (s-(-)- o levofloxacino, es el responsable de la actividad bactericida, se han evaluado tambi\u00e9n los enanti\u00f3meros de forma individualizada, en el fin de relacionar sus concentraciones plasmaticas con la eficacia.  se han realizado cultivos de bilis y calculos en 105 pacientes a lo largo de dos a\u00f1os, en los cultivos positivos(39) se han identificado los microorganismos y se han determinado mediante antibiograma las cmi frente a ofloxacino y pefloxacino. Los microorganismos aislados m\u00e1s frecuentes fueron excherichia coli, (25,3%),enterococcus faecium(9,3%), staphylococcus epidermidids(6,6%), y clostridium perfringens (6,6%). Escherichia coli fue sensible a ofloxacino y pefloxacino con unos valores de cmi90 de 0,125 ug\/ml para ambos antibi\u00f3ticos. Enterococcus faecum result\u00f3 resistente a ambos antibi\u00f3ticos, conuna cmi90 de 8 ug\/ml,aunque algunas cepas s\u00ed que fueron sensibles. Staphylococcus epidermidis y clostridium perfringens fueron sensibles con cmi90 de 0,25 ug\/ml y 1 ug\/ml para oflozacino y 0,5 ug\/ml y 1 ug\/ml para pefloxacino, respectivamente.  se ha realizado cin\u00e9tico plasm\u00e1tica en 20 pacientes (10 con ofloxacino y 10 con pefloxacino) y niveles tisulares en 31 pacientes (17 con ofloxacino y 14 con pefloxacino). La administraci\u00f3n de 400 mg de ofloxacino y 800 mg de pefloxacino mediante perfusi\u00f3n intravenosa de una hora de duraci\u00f3n, una hora antes de comanzar la intervenci\u00f3n quirurgica, proporciona niveles plasmaticas y tisu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocinetica-farmacodinamia de ofloxacino y pefloxacino en profilaxis de cirugia biliar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocinetica-farmacodinamia de ofloxacino y pefloxacino en profilaxis de cirugia biliar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eugenia Campo Cimarras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Mendez mertin <\/li>\n<li>Mar\u00eda  Jos\u00e9 Garcia sanchez (vocal)<\/li>\n<li>victor Jimenez torres (vocal)<\/li>\n<li>Andr\u00e9s Canut blasco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eugenia Campo Cimarras El objetivo de la presente memoria experimental ha consistido en comprobar la eficacia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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