{"id":86134,"date":"2018-03-10T00:10:42","date_gmt":"2018-03-10T00:10:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-indice-de-proliferacion-celular-en-el-carcinoma-prostatico-predice-el-riesgo-de-fallo-bioquimico-despues-de-la-prostatectomia\/"},"modified":"2018-03-10T00:10:42","modified_gmt":"2018-03-10T00:10:42","slug":"el-indice-de-proliferacion-celular-en-el-carcinoma-prostatico-predice-el-riesgo-de-fallo-bioquimico-despues-de-la-prostatectomia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-indice-de-proliferacion-celular-en-el-carcinoma-prostatico-predice-el-riesgo-de-fallo-bioquimico-despues-de-la-prostatectomia\/","title":{"rendered":"El indice de proliferacion celular en el carcinoma prostatico predice el riesgo de fallo bioquimico despues de la prostatectomia."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Diaz Mariscal Jos\u00e9 Ignacio <\/strong><\/h2>\n<p>Objetivo: evaluar si la determinaci\u00f3n de la ploidia del adn y el \u00edndice de proliferaci\u00f3 celular mediante an\u00e1lisis  citom\u00e9trico digitalizado es un procedimiento tecnicamente factible en las biopsias prost\u00e1ticas. Evaluar si estos dos factores se correlacionan positivamente con el grado de malignidad histol\u00f3gica del carcinoma prost\u00e1tico determinado mediante escor de gleason. evaluar si estos dos factores pueden predecir el riesgo de fallo bioqu\u00edmico despu\u00e9s de la prostectom\u00eda. Comparar su valor predictivo con el escor de gleason y determinar si su uso independiente o combinado es de utilidad clinica.  materiales y metodos:se estudiaron 16 pacientes con hiperplasia benigna de la prostata y 65 pacientes con carcinoma prost\u00e1tico. Los pacientes con carcinoma se subclasificaron seg\u00fan su escor de gleascon: escor de gleason 2-4 (14 casos), escor de gleason 5-6 (19 casos), escor de gleason 7 (14 cados) y escor de gleason  8-10 (18 casos).  todos los pacientes con carcinoma fueron tratados mediante prostatectomia y monitorizados despues de la cirugia con mediciones del antig\u00e9no prost\u00e1tico en sangre cada 6 meses. Los pacientes se dividieron en do grupos cl\u00ednicos : los que desarrollaron fallo bioqu\u00edmico y los que no (fallo bioqu\u00edmico si se detect\u00f3 psa&lt; 0,1 ng\/ml en 3 o m\u00e1s mediciones despu\u00e9s de la cirug\u00eda). la proligeraci\u00f3n celular se midi\u00f3 mediante indentificaci\u00f3n inmunohistoquimica (ki-67) y an\u00e1lisis del ciclo del adn. El conteo celular se efectuo con ordenador mediante citometr\u00eda digitalizada utilizando el analizador de im\u00e1genes cas-200.  resultados: todas las hiperplasias fueron diploides y con baja proliferaci\u00f3n celular. En contrate, los carcinomas fueron o bien diploides con alta proliferacion celular o aneuplides. La proliferaci\u00f3n celular fue significativamente m\u00e1s alta (p&lt;0,001)en los tumores con escor de gleason&gt; 6(% promedio de c\u00e9lulas ki-67 positivas= 18,3%) que en los tumores con escor de gleason &#038;<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El indice de proliferacion celular en el carcinoma prostatico predice el riesgo de fallo bioquimico despues de la prostatectomia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El indice de proliferacion celular en el carcinoma prostatico predice el riesgo de fallo bioquimico despues de la prostatectomia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Diaz Mariscal Jos\u00e9 Ignacio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Egido De Los Rios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Nistal mart\u00edn de serrano <\/li>\n<li>Francisco Mampaso martin buitrago (vocal)<\/li>\n<li>remigio Vela navarrete (vocal)<\/li>\n<li>Manuel S\u00e1nchez chapado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diaz Mariscal Jos\u00e9 Ignacio Objetivo: evaluar si la determinaci\u00f3n de la ploidia del adn y el \u00edndice [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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