{"id":86143,"date":"2018-03-10T00:10:42","date_gmt":"2018-03-10T00:10:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-del-proceso-de-muerte-apoptosis-en-celulas-leucemicas-por-agentes-antineoplasicos-y-tratamientos-de-estres\/"},"modified":"2018-03-10T00:10:42","modified_gmt":"2018-03-10T00:10:42","slug":"regulacion-del-proceso-de-muerte-apoptosis-en-celulas-leucemicas-por-agentes-antineoplasicos-y-tratamientos-de-estres","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-del-proceso-de-muerte-apoptosis-en-celulas-leucemicas-por-agentes-antineoplasicos-y-tratamientos-de-estres\/","title":{"rendered":"Regulaci\u00f3n del proceso de muerte (apoptosis) en c\u00e9lulas leuc\u00e9micas por agentes antineopl\u00e1sicos y tratamientos de estr\u00e9s."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gal\u00e1n Garc\u00eda M. Alba <\/strong><\/h2>\n<p>En este trabajo se han analizado algunos de los factores posiblemente implicados en la regulaci\u00f3n de la muerte celular en c\u00e9lulas leuc\u00e9micas mieloides, como el factor de transcripci\u00f3n ap-1, la oxidaci\u00f3n intracelular y distintas mapks. Como modelo celular se ha empleado la l\u00ednea leuc\u00e9mica promonoc\u00edtica humana u-937, y como inductores de murrte se han utilizado inductores de la respuesta de estr\u00e9s como el cadmio, el calor y los rayos x,y ocasionalmente agentes antinepl\u00e1sicos como la camptotecina y el estop\u00f3sido.  se ha demostrado que la activaci\u00f3n jun\/ap-1 no es requerida para la generaci\u00f3n de apoptosis por inductores de estr\u00e9s y agentes antineopl\u00e1sicos. adem\u00e1s, la actividaed jun\/ap-1 y la apoptosis no son fen\u00f3menos necesariamente acoplados.  tambi\u00e9n se ha analizado que la oxidaci\u00f3n intracelular no es un mediador universal de la generaci\u00f3n de apoptosis por inductores de estr\u00e9s y que la disminuci\u00f3n de los niveles intracelulares de glutationpotencia selectivamente la toxidad del cloruro de cambio provocando un cambio en el tipo de muerte celular de apoptosis a necrosis.  en relaci\u00f3n con las mapks se ha demostrado que la regulaci\u00f3n por p38 de la apoptosis inducida por cadmio es un evento altamente espec\u00edfico y temprano que posiblemente regula el disparo de la oxidaci\u00f3n celular.  finalmente hemos probado que la inducci\u00f3n de la respuesta de estr\u00e9s es compatible con la apoptosis pero no con la necrosis en c\u00e9lular tratadas con cadmio. La anulaci\u00f3n de la respuesta de estr\u00e9s durante la necrosis parece ser debida a la inhibici\u00f3n selectiva del procesamiento del factor de transcripci\u00f3n hsf1. Adem\u00e1s, en este modelo celular la ocurrencia de diversos fen\u00f3menos durante la necrosis sugiere que este tipo de muerte puede ser un proceso activo que comparte alguno de los pasos reguladores de la muerte apopt\u00f3tica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n del proceso de muerte (apoptosis) en c\u00e9lulas leuc\u00e9micas por agentes antineopl\u00e1sicos y tratamientos de estr\u00e9s.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n del proceso de muerte (apoptosis) en c\u00e9lulas leuc\u00e9micas por agentes antineopl\u00e1sicos y tratamientos de estr\u00e9s. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gal\u00e1n Garc\u00eda M. Alba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Patricio Aller Tresguerres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Prieto villap\u00fan <\/li>\n<li>augusto Silva gonzalez (vocal)<\/li>\n<li>pl\u00e1cido Navas lloret (vocal)<\/li>\n<li> De la rosa cano enrique (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gal\u00e1n Garc\u00eda M. Alba En este trabajo se han analizado algunos de los factores posiblemente implicados en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,849,160,115,35,2008,17],"tags":[14293,57049,180992,17527,17474,2023],"class_list":["post-86143","post","type-post","status-publish","format-standard","hentry","category-alcala","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-morfologia-celular","category-quimica","tag-augusto-silva-gonzalez","tag-de-la-rosa-cano-enrique","tag-galan-garcia-m-alba","tag-juan-carlos-prieto-villapun","tag-patricio-aller-tresguerres","tag-placido-navas-lloret"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86143"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86143\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}