{"id":86181,"date":"2018-03-10T00:10:42","date_gmt":"2018-03-10T00:10:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/exposiciones-laborales-y-activacion-del-gen-k-ras-en-la-etiologa%c2%ada-del-cancer-de-pancreas-exocrino\/"},"modified":"2018-03-10T00:10:42","modified_gmt":"2018-03-10T00:10:42","slug":"exposiciones-laborales-y-activacion-del-gen-k-ras-en-la-etiologa%c2%ada-del-cancer-de-pancreas-exocrino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/exposiciones-laborales-y-activacion-del-gen-k-ras-en-la-etiologa%c2%ada-del-cancer-de-pancreas-exocrino\/","title":{"rendered":"Exposiciones laborales y activaci\u00f3n del gen k-ras en la etiolog\u00eda del c\u00e1ncer de p\u00e1ncreas exocrino."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Alguacil Ojeda <\/strong><\/h2>\n<p>Los objetivos del presente trabajo fueronanalizar la relaci\u00f3n entre los antecedentes de exposiciones laborales y el riesgo de cpe en espa\u00f1a, por un lado, y analizar la asociaci\u00f3n entre estas exposiciones y la presencia de mutaciones en el gen k-ras en pacientes con cpe, por otro.  para abordar estos objetivos el presente trabajo se ha enmarcado dentro del estudio pankras ii, en el que se reclutaron 164 casos incidentes de cpe y 238 controles. El estudio caso-caso se basa en los 107 pacientes en cuyo material histol\u00f3gico se pudo analizar la presencia de mutaciones en el gen k-ras. La informaci\u00f3n sobre dieta, consumo de tabaco, alcohol y caf\u00e9, y factores cl\u00ednicos, socio-demogr\u00e1ficos y laborales se obtuvo mediante entrevista directa con el paciente. Se obtuvo as\u00ed la historia laboral de cada paciente, y laa ocupaciones referidas se clasificaron seg\u00fan la cno94. dos expertos higienistas industriales evaluaron la exposici\u00f3n laboral a 22 agentes qu\u00edmicos potencialmente asociados al cpe. Adem\u00e1s tambi\u00e9n se evalu\u00f3 la exposici\u00f3n laboral a 22 agentes qu\u00edmicos, dos f\u00edsicos, y uno ernon\u00f3mico mediante la matriz de exposici\u00f3n laboral finjem. En el an\u00e1lisis caso-caso se compararon las exposiciones laborales entre los pacientes con cpe mutado y los pacientes con cpe nomutado. El estimador de riesgo fue la raz\u00f3n de ods ajustada, calculada por regresi\u00f3n log\u00edstica no condicional.  respecto a al an\u00e1lisis caso-control, los resultados de este estudio apoyan la hip\u00f3tesis de una asociaci\u00f3n entre exposici\u00f3n a ciertos tipos de plaguicidas, anilinas y derivados y benzo(a)pireno y el riesgo de c\u00e1ncer de p\u00e1ncreas exocrino.  en cuanto al an\u00e1lisis caso-caso, las asociaciones encontradas entre exposici\u00f3n a disolventes org\u00e1nicos metales y pahs, y la activaci\u00f3n del gen k-ras merecen especial atenci\u00f3n y estudios con mayor profundidad. Ninguna de estas exposicones se asoci\u00f3 a una s\u00f3la mutaci\u00f3n espec\u00edfica en el gen k-ras. La exposici\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Exposiciones laborales y activaci\u00f3n del gen k-ras en la etiolog\u00eda del c\u00e1ncer de p\u00e1ncreas exocrino.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Exposiciones laborales y activaci\u00f3n del gen k-ras en la etiolog\u00eda del c\u00e1ncer de p\u00e1ncreas exocrino. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Alguacil Ojeda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miquel Porta Serra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gomez l\u00f3pez Luis ignacio <\/li>\n<li>manolis Kogevinas (vocal)<\/li>\n<li> Garc\u00eda Garc\u00eda Ana Mar\u00eda (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Alguacil Ojeda Los objetivos del presente trabajo fueronanalizar la relaci\u00f3n entre los antecedentes de exposiciones laborales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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