{"id":86268,"date":"2000-08-09T00:00:00","date_gmt":"2000-08-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-oxido-na%c2%adtrico-mineralcorticoides-efecto-sobre-el-control-de-la-presion-arterial-a-largo-plazo-y-morfologa%c2%ada-renal\/"},"modified":"2000-08-09T00:00:00","modified_gmt":"2000-08-09T00:00:00","slug":"interaccion-oxido-na%c2%adtrico-mineralcorticoides-efecto-sobre-el-control-de-la-presion-arterial-a-largo-plazo-y-morfologa%c2%ada-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interaccion-oxido-na%c2%adtrico-mineralcorticoides-efecto-sobre-el-control-de-la-presion-arterial-a-largo-plazo-y-morfologa%c2%ada-renal\/","title":{"rendered":"Interacci\u00f3n \u00f3xido n\u00edtrico-mineralcorticoides. efecto sobre el control de la presi\u00f3n arterial a largo plazo y morfolog\u00eda renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gracia \u00e1lvarez Fern\u00e1ndez <\/strong><\/h2>\n<p>Objetivos  1,- analizar la interacci\u00f3n no-mineralcoricoides y su efecto sobre t.A., funci\u00f3n renal y otras variables endocrinas.  2,- evaluar efectos de doca y l-name sobre la morfolog\u00eda renal.  material-metodo  ratas wistar macho, asignadas al azar a los grupos control (c); doca (d); l-name dosis presora (np); l-name dosis subpresora (nsp); d+nsp; d+np. todos los grupos se estudiaron bebiendo agua sola con clna al 1%. Durante 3 semanas se determin\u00f3 la presi\u00f3n arterial sist\u00f3lica (pas) por pletismografia en rabo, y al final por registro directo. Se obtuvieron muestras de sangre y orina para analizar diversas variables (funci\u00f3n renal, microalbuminaria, adh y endotelina en orina), y se realizaron estudios histol\u00f3gicos sobre los ri\u00f1ones.  resultados  la pas aument\u00f3 significativamente en el grupo d+nsp, permaneciendo normal en los grupos d y nsp. La administraci\u00f3n de nsp aceler\u00f3 el curso de la hipertensi\u00f3n doca-sal. La doca aceler\u00f3 el curso de la hipertensi\u00f3n l-name tanto en el grupo agua como en el salino. El l-name subpresor no aument\u00f3 la presi\u00f3n arterial en ratas que beb\u00edan salino. Histol\u00f3gicamente, todos los grupos salinos presentaban alteraciones en la morfolog\u00eda renal respecto a los controles, salvo el nsp. Dichas lesiones fueron m\u00e1s acusadas en el d+np, y en el dnsp, que present\u00f3 lesiones de m\u00e1s intensidad respecto a las doca-sal sola.  conclusiones  1,- la inhibici\u00f3n de la s\u00edntesis de \u00f3xido n\u00edtrico aumenta la sensibilidad del efecto presor de los mineralcorticoides, independientemente de la ingesta salina.  2,- el l-name y la doca tienen efectos aditivos sobre el aumento de presi\u00f3n arterial, desarrollo de la hipertrofia card\u00edaca y deterioro de funci\u00f3n renal, con independencia de la ingesta salina.  3,- la doca+l-name agrava las lesiones renales en las ratas con una elevada ingesta salina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacci\u00f3n \u00f3xido n\u00edtrico-mineralcorticoides. efecto sobre el control de la presi\u00f3n arterial a largo plazo y morfolog\u00eda renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacci\u00f3n \u00f3xido n\u00edtrico-mineralcorticoides. efecto sobre el control de la presi\u00f3n arterial a largo plazo y morfolog\u00eda renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gracia \u00e1lvarez Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 F\u00e9lix Vargas Palomares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Lopez novoa <\/li>\n<li>joaqu\u00edn Garc\u00eda-esta\u00f1 l\u00f3pez (vocal)<\/li>\n<li>raimundo Garc\u00eda delmoral garrido (vocal)<\/li>\n<li> Garc\u00eda del r\u00edo cipriano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gracia \u00e1lvarez Fern\u00e1ndez Objetivos 1,- analizar la interacci\u00f3n no-mineralcoricoides y su efecto sobre t.A., funci\u00f3n renal y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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