{"id":86270,"date":"2000-08-09T00:00:00","date_gmt":"2000-08-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-mycobacterium-avium-complex-y-estudio-de-la-diversidad-genetica-de-mycobacterium-avium-mediante-analisis-de-la-secuencia-de-insercion-is1245\/"},"modified":"2000-08-09T00:00:00","modified_gmt":"2000-08-09T00:00:00","slug":"caracterizacion-de-mycobacterium-avium-complex-y-estudio-de-la-diversidad-genetica-de-mycobacterium-avium-mediante-analisis-de-la-secuencia-de-insercion-is1245","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-mycobacterium-avium-complex-y-estudio-de-la-diversidad-genetica-de-mycobacterium-avium-mediante-analisis-de-la-secuencia-de-insercion-is1245\/","title":{"rendered":"Caracterizacion de mycobacterium avium complex y estudio de la diversidad gen\u00e9tica de mycobacterium avium mediante an\u00e1lisis de la secuencia de inserci\u00f3n is1245."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Mar\u00eda Navarro Cots <\/strong><\/h2>\n<p>Se ha realizado la identificaci\u00f3n al nivel de especie, mediante m\u00e9todos moleculares, de 83 aislados cl\u00ednicos de m. Avium complex (mac) obtenidos de 44 pacientes (29 vih positivos, 15 vih negativos), y se ha estudiado la sensibilidad a diez antibi\u00f3ticos y la diversidad gen\u00e9tica, mediante an\u00e1lisis del polimorfismo (rflp) de la secuencia de inserci\u00f3n is1245. La especie m\u00e1s prevalente fue m. Avium (94%), seguida de m. Intracellulare (2.4%) y mai-x(1.2%). Dos aislados (2.4%) no hibridaron con la sonda espec\u00edfica mac y fueron considerados variedades fenotipo mac. Los antibi\u00f3ticos m\u00e1s activos in vitro, con un 100% de aislados sensibles o moderadamente sensibles, fueron azitromicina, claritromicina y moxifloxacino, con cmi 90% de 16 mg\/l, 2 mg\/l y 1 mg\/l, respectivamente. Los restantes antibi\u00f3ticos mostraron escasa o nula actividad, exceptorifabutina que fue m\u00e1s activa que rifampicina. el estudio de los perfiles rflp demostr\u00f3 la existencia de un marcado polimorfismo, el n\u00famero de copias de is1245 dectectadas fue de tres a 27, con tama\u00f1os relativos comprendidos entre 0.9 y 20.7 kpb, y el 88.6% de los aislados presentaron al menos 10 copias de is1245. La secuencia is1245, fue detectada solo en el 100% de los aislados m. Avium y en un aislado identificado como fenotipo mac. La estabilidad in vitro de la secuencia fue excelente, pero in vivo se detectaron variaciones en un 53.9% de los casos. El an\u00e1lisis de los perfiles rflp permiti\u00f3 agrupar a los aislados en 26 grupos de restrici\u00f3n (p1 a p26) y el estudio temporal de los aislados de pacientes diferentes incluidos en un mismo grupo rfpl demostr\u00f3 la existencia de dos contaminaciones accidentales de laboratorio. El 80% de los pacientes presentaron patrones rflp exclusivos, el 68% con un \u00fanico patr\u00f3n, un 8% con dos patrones diferentes y un 4% con tres patrones distintos. Dos grupos rflp inclu\u00edan a aislados de diferentes pacientes, lo que supone un porcentaje de agrupamiento del 20%<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de mycobacterium avium complex y estudio de la diversidad gen\u00e9tica de mycobacterium avium mediante an\u00e1lisis de la secuencia de inserci\u00f3n is1245.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de mycobacterium avium complex y estudio de la diversidad gen\u00e9tica de mycobacterium avium mediante an\u00e1lisis de la secuencia de inserci\u00f3n is1245. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Mar\u00eda Navarro Cots <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Borr\u00e1s Salvador<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Hernandez gimenez <\/li>\n<li>Manuel Segovia hern\u00e1ndez (vocal)<\/li>\n<li>Juan Garcia de lomas barrionuevo (vocal)<\/li>\n<li>Manuel Hernandez perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Mar\u00eda Navarro Cots Se ha realizado la identificaci\u00f3n al nivel de especie, mediante m\u00e9todos moleculares, de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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