{"id":86274,"date":"2000-08-09T00:00:00","date_gmt":"2000-08-09T00:00:00","guid":{"rendered":""},"modified":"2000-08-09T00:00:00","modified_gmt":"2000-08-09T00:00:00","slug":"addicions-de-michael-catalitzades-per-niii-formacio-de-centres-quaternaris-i-addicions-diastereoselectives-de-4s-n-acetoacetil-4-benziloxazolidin-2-ona-sintesi-i-aplicacions-de-la-2-1-adamantil","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/addicions-de-michael-catalitzades-per-niii-formacio-de-centres-quaternaris-i-addicions-diastereoselectives-de-4s-n-acetoacetil-4-benziloxazolidin-2-ona-sintesi-i-aplicacions-de-la-2-1-adamantil\/","title":{"rendered":"Addicions de michael catalitzades per ni(ii). formacio de centres quaternaris i addicions diastereoselectives de (4s)-n-acetoacetil-4-benziloxazolidin-2-ona. sintesi i aplicacions de la 2-(1-adamantil)glicina enantiomericament pura."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaume Clariana Fresno <\/strong><\/h2>\n<p>Estudio de adiciones de michael en medio neutro catalizadas por complejos de ni(ii)y cu(ii), evitando de esta forma los inconvenientes presentados en el caso de utilizar la catalisis basica tradicional. Se han realizado estudios de reacciones de michael diastereoselectivas sobre la (4s)-n-acetoacetil-4-benziloxazolidin-2-ona frente a una amplia  variedad de electrofilos utilizando como catalizador el bis(salicilaldhidato) de ni(ii). Utilizando isocianatos de fenilo 4-substituidos se ha obtenido el primer 3,5-diaminopirazol opticamente puro descrito en la literatura. Tambien se ha demostrado que en las reacciones de michael sobre determinados compuestos b-dicarbonilicos es posible la generacion de centros cuaternarios trabajando en medio neutro bajo catalisis de complejos de ni(ii) y cu(ii).  por otra parte hemos puesto a punto un metodo optimizado de sintesis de la 2-(1-admantil)glicina y de su 1,2-aminoalcohol derivado con unos muy buenos rendimientos quimicos. Hemos llevado a cabo la resoluci\u00f3n optica de dichos compuestos mediante metodos biocataliticos determinando la configuracion a partir de un analisis por difraccion de rayos x. A partir de este 1,2-aminoalcohol se ha procedido a la sintesis de ligando bis(oxazolina) que contienen en su estructura el resto adamantil que les confiere una menor flexibilidad y una gran aplicablidad en catalisis asimetrica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Addicions de michael catalitzades per ni(ii). formacio de centres quaternaris i addicions diastereoselectives de (4s)-n-acetoacetil-4-benziloxazolidin-2-ona. sintesi i aplicacions de la 2-(1-adamantil)glicina enantiomericament pura.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Addicions de michael catalitzades per ni(ii). formacio de centres quaternaris i addicions diastereoselectives de (4s)-n-acetoacetil-4-benziloxazolidin-2-ona. sintesi i aplicacions de la 2-(1-adamantil)glicina enantiomericament pura. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaume Clariana Fresno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcial Moreno Ma\u00f1as<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Gotor santamar\u00eda <\/li>\n<li>Javier Garin (vocal)<\/li>\n<li>jordi Marquet cortes (vocal)<\/li>\n<li>amadeu Llebaria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaume Clariana Fresno Estudio de adiciones de michael en medio neutro catalizadas por complejos de ni(ii)y cu(ii), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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