{"id":86280,"date":"2000-08-09T00:00:00","date_gmt":"2000-08-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/optimizacion-del-tratamiento-antibacteriano-con-antibioticos-betalactamicos-evaluacion-de-la-interaccion-farmacocinetica-farmacodinamica\/"},"modified":"2000-08-09T00:00:00","modified_gmt":"2000-08-09T00:00:00","slug":"optimizacion-del-tratamiento-antibacteriano-con-antibioticos-betalactamicos-evaluacion-de-la-interaccion-farmacocinetica-farmacodinamica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/optimizacion-del-tratamiento-antibacteriano-con-antibioticos-betalactamicos-evaluacion-de-la-interaccion-farmacocinetica-farmacodinamica\/","title":{"rendered":"Optimizacion del tratamiento antibacteriano con antibioticos betalactamicos: evaluacion de la interaccion  farmacocinetica\/farmacodinamica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Belen Sadaba Diaz De Rada <\/strong><\/h2>\n<p>Tanto la susceptibilidad in vitro de un microorganismo como la farmacocin\u00e9tica del antibi\u00f3tico son los dos pilares fundamentales en los que se basa la elecci\u00f3n de las pautas estandarizadas, en la terap\u00e9utica antimicrobiana. pero no se tienen en cuenta las variaciones individuales en cada paciente, que modifican la exposicion de la bacteria al antibi\u00f3tico, en tiempo o en cantidad, de forma que los fracasos terap\u00e9uticos pueden deberse a que las concentraciones obtenidas con esta dosis estandar, no se adecuan a la sensibilidad del microorganismo responsable del proceso.  se estudiaron 87 pacientes en tratamiento con b-lact\u00e1micos (ceftriaxona, cefepima o piperacilina). La probabilidad de que la evoluci\u00f3n clinica fuera inadecuada se relaciono de forma significativa conla edad del paciente, la localizaci\u00f3n del proceso infeccioso en un tejido con dificultad a la difusi\u00f3n del b-lact\u00e1mico (osteomielitis, pr\u00f3stata, abscesos), la identificaci\u00f3n de pseudomonas aeruginosa como microorganismo responsable, concentraciones plasmaticas que no superaban a la cmi durante todo el intervalo de administraci\u00f3n y con valores bajos del par\u00e1metro auc0-24 sobre la cmi. La probabilidad de que las concentraciones plasm\u00e1ticas no superaran a la cmi durante todo el intervalo de administraci\u00f3n era significativamente superior cuando el paciente recibia piperacilina y presentaba una funci\u00f3n renal normal.  se observ\u00f3 que la evoluci\u00f3n era significativamente mejor cuando las concentraciones superaban a la cmi durante el 90% del intervalo de administraci\u00f3n, o cuando el cociente entre la concentraci\u00f3n plasm\u00e1tica minima y la cmi era superior a 1. Tambien se observ\u00f3 la misma tendencia si el auc0-24 sobre la cmi presentaba un valor superior a 750 mg x h\/1. Ni la posolog\u00eda ni la funci\u00f3n renal o las caracteristicas demogr\u00e1ficas de los pacientes eran predictores de la evoluci\u00f3n.  existe por tanto la posibilidad de modificar la posolog\u00eda, partiendo de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Optimizacion del tratamiento antibacteriano con antibioticos betalactamicos: evaluacion de la interaccion  farmacocinetica\/farmacodinamica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Optimizacion del tratamiento antibacteriano con antibioticos betalactamicos: evaluacion de la interaccion  farmacocinetica\/farmacodinamica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Belen Sadaba Diaz De Rada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Azanza Perea Jos\u00e9 Ramon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>ignacio Alberola gomez-escolar (vocal)<\/li>\n<li>Jos\u00e9 Luis Arribas llorente (vocal)<\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Belen Sadaba Diaz De Rada Tanto la susceptibilidad in vitro de un microorganismo como la farmacocin\u00e9tica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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