{"id":86311,"date":"2000-12-09T00:00:00","date_gmt":"2000-12-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-actividad-de-las-integrinas-alfa4-por-sdf-1alfa-y-tgf-beta1\/"},"modified":"2000-12-09T00:00:00","modified_gmt":"2000-12-09T00:00:00","slug":"modulacion-de-la-actividad-de-las-integrinas-alfa4-por-sdf-1alfa-y-tgf-beta1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-de-la-actividad-de-las-integrinas-alfa4-por-sdf-1alfa-y-tgf-beta1\/","title":{"rendered":"Modulacion de la actividad de las integrinas alfa4 por sdf-1alfa y tgf-beta1."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Sanz Rodriguez <\/strong><\/h2>\n<p>La integrina vla-4 media la adhesi\u00f3n de c\u00e9lulas de mieloma al estroma de m\u00e9dula \u00f3sea de mieloma m\u00faltiple (mm). La regi\u00f3n cs-1 de fibronectina (fn) y vcam-1 constituyen los principales ligandos de vla-4 y ambos se expresan en el estroma de mm. La regi\u00f3n h1, que est\u00e1 presente en todas las isoformas de fn, constituye un sitio de uni\u00f3n adicional para vla-4. Utilizamos los fragmentos de fn, fn-h89, fn-h0, que contienen la regi\u00f3n cs-1 y h1, o s\u00f3lo la regi\u00f3n h1, respectivamente, as\u00ed como una forma soluble de vcam-1 (svcam-1), para caracterizar las v\u00edas de adhesi\u00f3n mediadas por vla-4.  las c\u00e9lulas cd38highcd45ra de m\u00e9dula \u00f3sea de mieloma m\u00faltiple (mm), y las l\u00edneas celulares derivadas de mieloma, nci-h929, im-9 y rpmi8226, se adhirieron espec\u00edficamente, a diferentes niveles, a fn-h89, fn-h0 y a svcam-1, y su adhesi\u00f3n dependiente de vla-4 fue aumentada por el anticuerpo monoclonal anti-1 ts2\/16, el cual aumenta la afinidad y la avidez de las integrinas vla-1. Asimismo la funci\u00f3n de vla-4 sobre c\u00e9lulas nci-h929 fue aumentada por ts2\/16 durante su adhesi\u00f3n al estroma de mm. La integrina 4 7 medi\u00f3 una peque\u00f1a proporci\u00f3n de la adhesi\u00f3n de l\u00edneas celulares derivadas de mieloma a fn-h89, principalmente bajo la activaci\u00f3n de la integrina con mn2+. Todos estos datos indican que las c\u00e9lulas de mieloma utilizan las v\u00edas adhesi\u00f3n vla-4\/cs-1\/fn, vla-4\/h1\/fn y vla-4\/vcam-1 para mediar su adhesi\u00f3n al estroma de mm, y sugiriendo que la actividad adhesiva de esta integrina puede ser modulada, haciendo posible que estas c\u00e9lulas se adhieran en mayor grado a estos ligandos de vla-4, lo cual podr\u00eda influir en la localizaci\u00f3n de las c\u00e9lulas de mieloma en la m\u00e9dula \u00f3sea.  la quimioquina sdf-1 desarrolla su funci\u00f3n tras unirse a su receptor cxcr4. en este trabajo hemos demostrado que las c\u00e9lulas cd38highcd45ra- de m\u00e9dula \u00f3sea de mm y l\u00edneas celulares derivadas de mieloma expresaban cxcr4 y mostraban una respuesta quimiot\u00e1ct<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la actividad de las integrinas alfa4 por sdf-1alfa y tgf-beta1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la actividad de las integrinas alfa4 por sdf-1alfa y tgf-beta1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Sanz Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Teixid\u00f3 Calvo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ortiz de landazuri <\/li>\n<li>paloma S\u00e1nchez-mateos rubio (vocal)<\/li>\n<li>Manuel Fresno (vocal)<\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Sanz Rodriguez La integrina vla-4 media la adhesi\u00f3n de c\u00e9lulas de mieloma al estroma de m\u00e9dula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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