{"id":8644,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/sintesis-estereoselectiva-de-gamma-butirolactonas-y-espiroacetales-45-a-partir-de-vinil-sulfonas\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"sintesis-estereoselectiva-de-gamma-butirolactonas-y-espiroacetales-45-a-partir-de-vinil-sulfonas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-estereoselectiva-de-gamma-butirolactonas-y-espiroacetales-45-a-partir-de-vinil-sulfonas\/","title":{"rendered":"Sintesis estereoselectiva de gamma-butirolactonas y espiroacetales (4,5) a partir de vinil sulfonas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rojo Marcos Francisco Javier <\/strong><\/h2>\n<p>Se ha desarrollado un metodo de sintesis estereoselectiva de g-butiro-lactonas cis y trans disustituidas a partir de esteres a-(fenilsulfonil) a,b-insaturados y 3-(fenilsulfonil)-butenolidas, mediante la adicion de reactivos organoaluminicos. Esta metodolog\u00eda se ha aplicado a la preparacion estereo y enantioselectiva de la (-)-cis lactona del co\u00f1ac. Dicha lactona se ha obtenido opticamente pura, en 7 etapas y con un rdto.  global del 22%, lo que hace de esta sintesis la mas eficaz de las descritas en la bibliografia.  tambien se ha desarrollado un nuevo metodo convergente de sintesis de espiroacetales (4,5) que transcurre en una unica etapa sintetica a partir de dos precursores muy accesibles como son los 3-(fenilsulfonil) -4,5-dihidrofuranos y g-lactonas. El proceso de espiroacetalizacion tiene lugar con elevada estereoselectividad en c-7, c-5 y c-4 y con una estereoselectividad en c-2 dependiente del volumen esterico del sustituyente del dihidrofurano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis estereoselectiva de gamma-butirolactonas y espiroacetales (4,5) a partir de vinil sulfonas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis estereoselectiva de gamma-butirolactonas y espiroacetales (4,5) a partir de vinil sulfonas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rojo Marcos Francisco Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Carretero Gonz\u00e1lvez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Garc\u00eda Ruano <\/li>\n<li>Claudio Palomo Nicolau (vocal)<\/li>\n<li>Miguel \u00e1ngel Yus Astiz (vocal)<\/li>\n<li>Joaquin Plumet Ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rojo Marcos Francisco Javier Se ha desarrollado un metodo de sintesis estereoselectiva de g-butiro-lactonas cis y trans [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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