{"id":86483,"date":"2018-03-10T00:11:03","date_gmt":"2018-03-10T00:11:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesi-evaluacio-immunologica-i-estudi-estructural-de-construccions-pepta%c2%addiques-relacionades-emb-el-virus-de-la-febre-aftosa\/"},"modified":"2018-03-10T00:11:03","modified_gmt":"2018-03-10T00:11:03","slug":"sa%c2%adntesi-evaluacio-immunologica-i-estudi-estructural-de-construccions-pepta%c2%addiques-relacionades-emb-el-virus-de-la-febre-aftosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sa%c2%adntesi-evaluacio-immunologica-i-estudi-estructural-de-construccions-pepta%c2%addiques-relacionades-emb-el-virus-de-la-febre-aftosa\/","title":{"rendered":"S\u00edntesi, evaluaci\u00f3 immunol\u00f3gica i estudi estructural de construccions pept\u00eddiques relacionades emb el virus de la febre aftosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Roig Moreno <\/strong><\/h2>\n<p>La fiebre aftosa o glosopeda es una importante enfermedad v\u00edrica que afecta un ungulados dom\u00e9sticos y salvajes. Es especialmente temida por las graves consecuencias econ\u00f3micas que comportan para la ganader\u00eda. Por lo que respecta a su distribuci\u00f3n mundial, es end\u00e9mica en am\u00e9rica del sur, \u00e1frica y asia. En europa occidental se considera erradicada desde 1989. la enfermedad se ha controlado tradicionalmente mediante la vacunaci\u00f3n y el sacrificio de animales infectados.  en el presente trabajo se han planteado tres objetivos:  1,- preparaci\u00f3n de una vacuna sint\u00e9tica contra el virus de la fiebre aftosa para dos serotipos c-s8 y c3 argentina 85.  2,- estudio estructural de p\u00e9ptidos que mimetizan mutaciones que aparecen en el bucle inmunodominante del virus de serotipo c-s8c1.  3,- estudio conformacional de p\u00e9ptidos que mimetizan el bucle inmunodominante del virus c-s8c1.  para el desarrollo las vacunas se han sintetizado qu\u00edmicamente p\u00e9ptidos quim\u00e9ricos que contienen los lugares antig\u00e9nicos a y c del virus (ep\u00edtopos b). En dos contrucciones pept\u00eddicas se han incorporado, adem\u00e1s, ep\u00edtopos t de bovinos para mejorar la respuesta inmune de los hu\u00e9spedes contra una infecci\u00f3n experimental con virus hom\u00f3logo. Los p\u00e9ptidos fueron sintetizados en fase s\u00f3lida, de manera automatizada sobre un soporte polim\u00e9rico de tipo metilbenzhidrilamina y siguiendo una t\u00e1ctica de s\u00edntesis boc\/bencilo.  posteriormente, fueron purificados con m\u00e9todos cromatogr\u00e1ficos y caracterizados mediante espectrometr\u00eda de masas. La evaluaci\u00f3n inmunol\u00f3gica de los inmun\u00f3genos pept\u00eddicos fue llevada a cabo en colaboraci\u00f3n con dos laboratorios veterinarios de espa\u00f1a y argentina. La eficacia de las vacunas sint\u00e9ticas fue modesta debido a la limitada representaci\u00f3n de lugares antig\u00e9nicos en los p\u00e9ptidos y a la aparici\u00f3n de virus mutantes durante la infecci\u00f3n experimental de los animales.  uno de los problemas  que dificulta el control de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesi, evaluaci\u00f3 immunol\u00f3gica i estudi estructural de construccions pept\u00eddiques relacionades emb el virus de la febre aftosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesi, evaluaci\u00f3 immunol\u00f3gica i estudi estructural de construccions pept\u00eddiques relacionades emb el virus de la febre aftosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Roig Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Andreu Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Pedroso muller <\/li>\n<li>francisca Reig isart (vocal)<\/li>\n<li>Miguel Feliz rodenas (vocal)<\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Roig Moreno La fiebre aftosa o glosopeda es una importante enfermedad v\u00edrica que afecta un ungulados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,160,2148,969,17],"tags":[5628,1101,5645,33679,67861,181519],"class_list":["post-86483","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-bioquimica","category-bioquimica-inmunologica","category-peptidos","category-quimica","tag-david-andreu-Martinez","tag-enrique-pedroso-muller","tag-esteban-domingo-solans","tag-francisca-reig-isart","tag-miguel-feliz-rodenas","tag-xavier-roig-moreno"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86483"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86483\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}