{"id":86504,"date":"2018-03-10T00:11:07","date_gmt":"2018-03-10T00:11:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-desarrollo-del-macizo-craneofacial-y-del-globo-ocular-en-un-modelo-de-hipotiroidismo-congenito-neonatal-en-la-rata\/"},"modified":"2018-03-10T00:11:07","modified_gmt":"2018-03-10T00:11:07","slug":"estudio-del-desarrollo-del-macizo-craneofacial-y-del-globo-ocular-en-un-modelo-de-hipotiroidismo-congenito-neonatal-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-desarrollo-del-macizo-craneofacial-y-del-globo-ocular-en-un-modelo-de-hipotiroidismo-congenito-neonatal-en-la-rata\/","title":{"rendered":"Estudio del desarrollo del macizo craneofacial y del globo ocular en un modelo de hipotiroidismo congenito neonatal en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gamborino Jorda M. Jose <\/strong><\/h2>\n<p>Nuestro objetivo es identificar factores que regulen procesos de diferenciaci\u00f3n y proliferaci\u00f3n celular en el globo ocular y tejidos anexos, cuya alteraci\u00f3n estuviera relacionada con la aparici\u00f3n de dismorfog\u00e9nesis ocular. Bas\u00e1ndonos en publicaciones que demuestran que la hormona tiroidea (ht) modula la expresi\u00f3n g\u00e9nica en el cerebro,m hemos estudiado si el hipotiroidismo cong\u00e9nito-neonatal (hpcn) inducido experimentalmente en la rata gestante (g) interfiere en el desarrollo embrionario de estructuras del macizo craneofacial y esbozo ocular y particularmente en la ontog\u00e9nesis de la retina. El hpcn se logr\u00f3 mediante administraci\u00f3n ininterrumpida a las ratas en el agua de bebida, desde el d\u00eda 9g hasta que concluye la lactancia de las cr\u00edas, del antibiroideo de s\u00edntesis metil-mercapto-imidazol (0.02%), efectuando una tiroidectom\u00eda total a las cr\u00edas el d\u00eda 5 tras el nacimiento. As\u00ed mediante radioinmunoensayo se detectaron niveles circulantes muy bajos de ht, extrapolables a los de mujeres cuya descendencia padec\u00eda el cretinismo. Junto a las hipotiroideas (gh) se mantuvieron en paralelo un grupo de ratas no tratadas (gc). Obtenidas las cabezas pre- (p) y postnatalmente (p) se procesaron para t\u00e9cnicas morfol\u00f3gicas y morfom\u00e9tricas a microscop\u00eda (m.) Electr\u00f3nica (e.) De barrido. Los ojos se obtuvieron p y p y se destinaron a examen macrosc\u00f3pico y t\u00e9cnicas morfol\u00f3gicas y morfom\u00e9tricas a m. \u00f3ptica y m.E. De transmisi\u00f3n. Los resultados sugieren que el hpnc provoca el retraso en la formaci\u00f3n de estructuras orbitarias y del esbozo ocular, con disminuci\u00f3n significativa de los ejes oculonasal<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del desarrollo del macizo craneofacial y del globo ocular en un modelo de hipotiroidismo congenito neonatal en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del desarrollo del macizo craneofacial y del globo ocular en un modelo de hipotiroidismo congenito neonatal en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gamborino Jorda M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pinazo Duran M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Gonzalez tomas <\/li>\n<li> Ramirez sebastian Jos\u00e9 m. (vocal)<\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>Jaime Renau piqueras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gamborino Jorda M. Jose Nuestro objetivo es identificar factores que regulen procesos de diferenciaci\u00f3n y proliferaci\u00f3n celular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,2606],"tags":[15488,181550,19177,27267,163988,55956],"class_list":["post-86504","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-ocular","tag-alberto-munoz-terol","tag-gamborino-jorda-m-jose","tag-jaime-renau-piqueras","tag-jose-gonzalez-tomas","tag-pinazo-duran-m-dolores","tag-ramirez-sebastian-jose-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86504"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86504\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}