{"id":86507,"date":"2018-03-10T00:11:07","date_gmt":"2018-03-10T00:11:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-antiinflamatoria-de-un-benzoquinona-de-origen-natural-rapanona\/"},"modified":"2018-03-10T00:11:07","modified_gmt":"2018-03-10T00:11:07","slug":"estudio-de-la-actividad-antiinflamatoria-de-un-benzoquinona-de-origen-natural-rapanona","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-actividad-antiinflamatoria-de-un-benzoquinona-de-origen-natural-rapanona\/","title":{"rendered":"Estudio de la actividad antiinflamatoria de un benzoquinona de origen natural: rapanona"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ospina Giraldo Luis Fernando <\/strong><\/h2>\n<p>Los productos naturales provenientes de las plantas medicinales representan una alternativa interesante en la busqueda de sustancias con posibles utilidad terapeutica en el control de diversos procesos inflamatorios. La meta a largo plazo de esta tesis es contribuir al conocimiento farmacol\u00f3gico de la flora medicinal colombina. El objetivo especifico de nuestro trabajo experimental ha sido la evaluaci\u00f3n de lo posible actividad antiinflamatoria y antioxidante de rapanona, una dihidroxibenxoquinona aislada de la corteza de myrsine guianensis(myrsinaceae), tanto in vitro(comportamiento frente a diversos mediadores como la pla2, radical super\u00f3xido, diversas enzimas,et&#8230;) como in vivo(modelos de bolsa de aire en rat\u00f3n, edema plantar por carragenina, edema auricular por forbol, inflamaci\u00f3n cronica por adyuvante, etc.), Con la intenci\u00f3n de constatar su potencial inter\u00e9s como f\u00e1rmaco antiinflamatorio.  se ha obtenido in vitro un potente efecto inhibidor de rapanona sobre la pla2 sinoval humana con una ci50 de 2,6 um, superior incluso al observado para el inhibidor de referencia manoalida. Este comportamiento inhibidor es muy selectivo, pues en mucha menor intensidad act\u00faa sobre otras isoformas(pla2 veneno de abeja, pla2 pancre\u00e1tica porcina, pla2 proveniente del exudado de bolsa de aire en rata estimulado por zimosan) o bien carece de efecto(pla2 de naja naja o pla2 citos\u00f3lica).  rapanona inhibi\u00f3 potentemente la generaci\u00f3n del radical ani\u00f3n super\u00f3xido en neutr\u00f3filos humanos estimulados con tpa, con un ci50 de 3 um. Es interesante rese\u00f1ar que rapanona igualmente se comport\u00f3 como un potente captador de dicho radical en el sistema qu\u00edmico de generaci\u00f3n hipoxantina\/xantina oxidasa, si bien con una ci50 de 7 um. Adicionalmente, rapanona inhibi\u00f3 el proceso de peroxidaci\u00f3n lip\u00eddica en microsomas hep\u00e1ticos de rata(ci50=48,1 um). asimismo, rapanona inhibi\u00f3 el proceso desgranulatoio en neutr\u00f3filos humanos estimulados con el sistem<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad antiinflamatoria de un benzoquinona de origen natural: rapanona<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad antiinflamatoria de un benzoquinona de origen natural: rapanona <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ospina Giraldo Luis Fernando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jos\u00e9 Alcaraz Tormo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo San feliciano martin <\/li>\n<li>Manuel Lamela gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Sepulveda arques (vocal)<\/li>\n<li> De las heras polo beatria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ospina Giraldo Luis Fernando Los productos naturales provenientes de las plantas medicinales representan una alternativa interesante en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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