{"id":86529,"date":"2018-03-10T00:11:07","date_gmt":"2018-03-10T00:11:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genes-c4-y-factor-b-del-complemento-analisis-molecular-polimorfismo-y-mecanismos-de-generacion\/"},"modified":"2018-03-10T00:11:07","modified_gmt":"2018-03-10T00:11:07","slug":"genes-c4-y-factor-b-del-complemento-analisis-molecular-polimorfismo-y-mecanismos-de-generacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/genes-c4-y-factor-b-del-complemento-analisis-molecular-polimorfismo-y-mecanismos-de-generacion\/","title":{"rendered":"Genes c4 y factor b del complemento: analisis molecular, polimorfismo y mecanismos de generacion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Lopez Goyanes <\/strong><\/h2>\n<p>El sistema del complemento consituye una de las barreras primarias de protecci\u00f3n de los vertebradso frente a las infecciones por microorganismo pat\u00f3genos. Su conocimiento en profundidad ha proporcionado y puede proporcionar herramientas diagn\u00f3sticas y terape\u00faticas para inmunodeficiencias causadas por defectos en el funcionammiento de dicho sistema.  las prote\u00ednas c4 y factor b del complemento son componentes, respectivamente, de las denomiandas \u00c2\u00b7v\u00eda cl\u00e1sica\u00bb\u00bb y \u00ab\u00bbv\u00eda alternativa\u00bb\u00bb del sistema del complemento. los genes que codifican para estas prote\u00ednas presentan, enla poblaci\u00f3n humana, cierto grado de polomorfismo, m\u00e1s acusado en el caso del gen c4 que en el del factor b, que indica la flexibilidad y adaptabilidad de este sistema de protecci\u00f3n inmunol\u00f3gica.  en un parte del presente trabajo se han secuenciado y caracterizado 3 nuevos alelos del gen c4 denominados c4a13, c4b12 y c4b93. El estudio de la regi\u00f3n polom\u00f3rfica de \u00e9stos y de los dem\u00e1s alelos de c4 conocidos ha permitido caracterizar 2 regiones gen\u00f3micas susceptibles de participar en mecanismos de recombinaci\u00f3n, lo que ha llevado a pensar que dichos mecanismo pueden ser los responsables de gran parte del polomorfismo encontrado en los genes c4.  por otra parte, tambi\u00e9n se han secuenciado en su totalidad y caracterizado los alelos m\u00e1s frecuentes del factor b denominados bf*fa, bf*fb y bf*s. sus secuencias se han comparado entre si y se han determinado las variaciones entre ellas, lo que ha llevado a la conclusi\u00f3nd e que el gen bf presenta un grado de polomorfismo muy reducido que puede explicarse, principalmente, mediante mecanismos de mutuaci\u00f3n puntual. La secunciaci\u00f3n completa de estos 3 alelosha permitido descubrir, adem\u00e1s, una nueva variante del alelo bf*s denominada bf*s (i).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genes c4 y factor b del complemento: analisis molecular, polimorfismo y mecanismos de generacion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genes c4 y factor b del complemento: analisis molecular, polimorfismo y mecanismos de generacion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Lopez Goyanes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>villena Arnaiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>Jos\u00e9 Luis Vicario  moreno (vocal)<\/li>\n<li>Santiago Rodriguez de cordoba (vocal)<\/li>\n<li> Martin gallardo Mar\u00eda  antonia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Lopez Goyanes El sistema del complemento consituye una de las barreras primarias de protecci\u00f3n de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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