{"id":86693,"date":"2018-03-10T00:11:20","date_gmt":"2018-03-10T00:11:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-de-dominios-estructurales-del-transportador-neuronal-de-glicina-glyt2\/"},"modified":"2018-03-10T00:11:20","modified_gmt":"2018-03-10T00:11:20","slug":"caracterizacion-funcional-de-dominios-estructurales-del-transportador-neuronal-de-glicina-glyt2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-funcional-de-dominios-estructurales-del-transportador-neuronal-de-glicina-glyt2\/","title":{"rendered":"Caracterizacion funcional de dominios estructurales del transportador neuronal de glicina glyt2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rodrigo Martinez Maza <\/strong><\/h2>\n<p>La glicina es el principal neurotransmisor inhibidor junto con el gaba, es el sistema nervioso central de mamiferos. Su acci\u00f3n finaliza mediante recaptura espec\u00edfica de la hendidura sinaptica a traves de los transportadores de alta afinidad. Glyt1 y glyt2, localizados en la membrana plasm\u00e1tica de neuronas y c\u00e9lulas de gl\u00eda. Para conocer el mecanismo de funcionamiento de la neurotransmisi\u00f3n mediada por glicina, es necesario un estudio detallado de su estructura y biolog\u00eda molecular.  en este trabajo hemos estudiado el papel funcional de diferentes dominios estructurales de los transportadores de glicina mediante la utilizaci\u00f3n de t\u00e9cnicas bioqu\u00edmicas, de biolog\u00eda molecular y electrofisiol\u00f3gicas. Para este fin nos hemos planteado los siguientes objetivos:1.- Analisis de las propiedades diferenciales de los transportadores glyt1 y glyt2 en lineas celulares que expresan de forma estable estas proteinas.2.-Caracterizacion del papel funcional de los siguientes dominios estructurales en la actividad del transportador glyt2:a) regiones amino y carboxilo terminal. B) cadenas oligosacar\u00eddicas unidas a residuos de asparagina(n-glicosilaci\u00f3n). C)bucles hidrof\u00edlicos extracelulares que unen dominos transmembrana.  se han hallado diferencias funcionales y electrofisiol\u00f3gicas entre los dos transportadores de glicina especificos del snc,glyt1b y glyt2a,mediante la comparaci\u00f3n de sus actividades en un sistema heter\u00f3logo de expresi\u00f3n estable. Glyt2 presenta diferente perfil farmacol\u00f3gio que glyt1, una menor afinidad aparente por el i\u00f3n c1, un mayor acoplamiento al gradiante quimiosm\u00f3tico de na+y una mayor dependencia del voltaje de las corrientes producidas tanto en presencia como ausencia de sustrato. Los extremos amino y carboxilo terminales de glyt2 se localizan al igual que en el caso de glyt1 en el interior celular. Estos dominios no afectan directamente a la actividad funcional del transporador sino que participan en la inserci\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion funcional de dominios estructurales del transportador neuronal de glicina glyt2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion funcional de dominios estructurales del transportador neuronal de glicina glyt2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rodrigo Martinez Maza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Arag\u00f3n Rueda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Gavilanes franco <\/li>\n<li>mar\u00ed\u00a7al Pastor anglada (vocal)<\/li>\n<li>Francisco Luis Moreno mu\u00f1oz (vocal)<\/li>\n<li>Luis Barrio calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodrigo Martinez Maza La glicina es el principal neurotransmisor inhibidor junto con el gaba, es el sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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