{"id":86702,"date":"2018-03-10T00:11:20","date_gmt":"2018-03-10T00:11:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nanoparticulas-de-albumina-para-la-adminsitracion-de-ganciclovir\/"},"modified":"2018-03-10T00:11:20","modified_gmt":"2018-03-10T00:11:20","slug":"nanoparticulas-de-albumina-para-la-adminsitracion-de-ganciclovir","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nanoparticulas-de-albumina-para-la-adminsitracion-de-ganciclovir\/","title":{"rendered":"Nanoparticulas de albumina para la adminsitraci\u00f3n de ganciclovir"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Merodio De La Quintana Marta <\/strong><\/h2>\n<p>El ganciclovir (gcv) es un an\u00e1logo sint\u00e9tico de la guanina muy empleado en el tratamiento de infecciones v\u00edricas oportunistas que afectan a pacientes inmunocomprometidos, especialmente a quellos afectados con el virus hiv y a los trasplantados. Destaca por ser la terapia de elecci\u00f3n en el tratamiento de afecciones por citomegalovirus (cmv).  las principales manifestaciones cl\u00ednicas de esta patolog\u00eda son la hepatitis, pneumontis y sobre todo la retinitis que, sin tratamiento, conduce a ceguera. el mecanismo de acci\u00f3n de este agente antiviral requiere su fosforilaci\u00f3n por quinasas celulares, preferentemente en celulas infectadas, dando lugar al ganciclovir-trifosfato.  esta forma activa inhibe la sintesis de la cadena  de adn viral en crecimiento. el inconveniente de este mecansimo es su efecto virost\u00e1tico; de ah\u00ed que, la infecci\u00f3n recurre en muchos pacientes al interrumpir el tratamiento. esto, junto con la aparici\u00f3n de resitencias ha llevado a plantear la necesidad de nuevos sitemas de administraci\u00f3n de este agente antiviral. As\u00ed, el objetivo de este trabajo de tesis es el desarrollo y posterior evaluaci\u00f3n de nuevas formas farmac\u00e9uticas de tipo nanopart\u00edcula destinadas a la administraci\u00f3n del ganciclovir.  la adsorci\u00f3n y\/o uni\u00f3n superficial de f\u00e1rmaco permite mejorar significativamente la eficacia anti-cmv de la terapia convencional, ya que las nuevas formulaciones desarrolladas incrementan notablemente la captura celular de f\u00e1rmaco. Los valores de ic50 pueden reducirse en un 45% enfibrolbastos de c\u00f3rne a y hasta en un 70% enfibroblastos de pulm\u00f3n embrionario. Esta eficacia se ve adem\u00e1s favorecida por la disminuci\u00f3n en el in\u00f3culo viral y por el retraso de 48h en el comienzo del tratamiento.  no obstante, la citotoxicidad inducida por altas concentraciones de ganciclovir se reduce cuando el f\u00e1rmaco se encuentra mayoritariamente atrapado en la nanopart\u00edcula. Por otro lado, las nanopart\u00edculas con ganciclovir<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nanoparticulas de albumina para la adminsitraci\u00f3n de ganciclovir<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nanoparticulas de albumina para la adminsitraci\u00f3n de ganciclovir <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Merodio De La Quintana Marta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/09\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Manuel Irache Garreta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li> Almeida Antonio  Jos\u00e9 leitao (vocal)<\/li>\n<li>philippe Legrand (vocal)<\/li>\n<li> Tros de ilarduya apaolaza Mar\u00eda  concepcion (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Merodio De La Quintana Marta El ganciclovir (gcv) es un an\u00e1logo sint\u00e9tico de la guanina muy empleado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1085,2445,957,139,17749],"tags":[181861,17998,43303,56304,98155,47838],"class_list":["post-86702","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-enfermedades-infecciosas","category-evaluacion-de-farmacos","category-farmacologia","category-medicina-interna","category-navarra","tag-almeida-antonio-jose-leitao","tag-edurne-cenarruzabeitia-sagarminaga","tag-juan-manuel-irache-garreta","tag-merodio-de-la-quintana-marta","tag-philippe-legrand","tag-tros-de-ilarduya-apaolaza-maria-concepcion"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86702"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86702\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}