{"id":86790,"date":"2000-05-10T00:00:00","date_gmt":"2000-05-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adhesion-y-movilidad-de-los-querotinocitos-humanos-integrinas-beta1-y-tetraspaninas\/"},"modified":"2000-05-10T00:00:00","modified_gmt":"2000-05-10T00:00:00","slug":"adhesion-y-movilidad-de-los-querotinocitos-humanos-integrinas-beta1-y-tetraspaninas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/adhesion-y-movilidad-de-los-querotinocitos-humanos-integrinas-beta1-y-tetraspaninas\/","title":{"rendered":"Adhesion y movilidad de los querotinocitos humanos: integrinas beta1 y tetraspaninas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Fernandez Pe\u00f1as <\/strong><\/h2>\n<p>En la epidermis normal, la expresi\u00f3n de integrinas b1 se limita a la capa basal. En la psoriasis se ha encontrado expresi\u00f3n suprabasal de integrinas b1 y se ha sugerido que pudiera ser un factor patog\u00e9nico, sin embargo el estado funcional de estas integrinas no ha sido estudiado. Para ello utilizamos anticuerpos monoclonales que reconocien el estado activado de las integrinas b1. Hemos encontrado que los queratinocitos (qc) expresan estos ep\u00edtopos de activaci\u00f3n y que estos epitopos pueden ser modulados por manganeso. adem\u00e1s, su expresi\u00f3n se relaciona con un aumento de la adhesi\u00f3n a fibronectina y col\u00e1geno. Los estudios de inmunohistoqu\u00edmica en piel sana y psoriasis indican que aunque existe una expresi\u00f3n suprabasal de integrinas b1 en la psoriasis, estas mol\u00e9culas parecen estar inactivas. Adem\u00e1s, la mayor parte de las integrinas b1 en la psoriasis, estas mol\u00e9culas parecen estar inactivas. Adem\u00e1s, la mayor parte de las integrinas en caras laterales y apicales de los qc de la capa basal tambi\u00e9n est\u00e1n en conformaci\u00f3n no activa, implicando una disminuci\u00f3n de la actividad comparada con la piel normal, en la que las integrinas b1 en conformaci\u00f3n activa est\u00e1n distribuidas en toda la membrana de los qc basales. Las tetraspaninas han sido implicadas en el modulaci\u00f3n de la actividad de las integrinas. Hemos encontrado que cd9 y cd81 se expresan abundantemente en la membrana de los qc y cd63 y cd151 principalmente en el compartimenteo intracelular. Hemos encontrado ac\u00famulos de cd9, cd81 y cd151 junto con integrinas a3 y b1 en las uniones intercelulares. Adem\u00e1s, encontramos expresi\u00f3n de cd9, cd81 e integrinas b1 y a3 en las huellas de los qc en movimiento, sugiriendo un papel en adhesi\u00f3n en matriz extracelular y en la migraci\u00f3n. Las integrinas b1 estaban s\u00f3lo parcialmente activadas en las huellas, y no se observaron proteinas de enlace con el citoesqueleto de la adhesi\u00f3n focal como la talina. Por otro lado, no encontramos t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Adhesion y movilidad de los querotinocitos humanos: integrinas beta1 y tetraspaninas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Adhesion y movilidad de los querotinocitos humanos: integrinas beta1 y tetraspaninas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Fernandez Pe\u00f1as <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amaro Garcia Diez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>evaristo Sanchez yus (vocal)<\/li>\n<li>Luis Iglesias diez (vocal)<\/li>\n<li>Javier Fraga fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Fernandez Pe\u00f1as En la epidermis normal, la expresi\u00f3n de integrinas b1 se limita a la capa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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