{"id":86806,"date":"2000-06-10T00:00:00","date_gmt":"2000-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-requerimientos-estericos-de-la-parte-no-farmacoforica-en-la-afinidad-selecticidad-por-el-receptor-5-ht-1a\/"},"modified":"2000-06-10T00:00:00","modified_gmt":"2000-06-10T00:00:00","slug":"estudio-de-los-requerimientos-estericos-de-la-parte-no-farmacoforica-en-la-afinidad-selecticidad-por-el-receptor-5-ht-1a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-los-requerimientos-estericos-de-la-parte-no-farmacoforica-en-la-afinidad-selecticidad-por-el-receptor-5-ht-1a\/","title":{"rendered":"Estudio de los requerimientos estericos de la parte no farmacoforica en la afinidad\/selecticidad por el receptor 5-ht 1a."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tandu K. Rovat Lucas <\/strong><\/h2>\n<p>La presente tesis doctoral titulada \u00abestudio de los requerimientos est\u00e9ricos de la parte no farmacof\u00f3rica en la afinidad\/selectividad por el receptor 5-*ht1a\u00bb ha sonsititdo en la s\u00edntesis y desarrollo de nuevos derivados de imida-arilpiperazina cona finidad y\/o selectividad por los recptores seroton\u00e9rgicos 5-ht1a y adren\u00e9rgico a1. Mediante estudios de relaci\u00f3n estrucurra-afinidad (safir) se ha evaluado los requerimientos est\u00e9ricos en la zona no farmacof\u00f3rica de las cavidades recptoriales seroton\u00e9rgica y adren\u00e9rgica, observ\u00e1ndose alguna diferencia est\u00e9rica importante entre ellos, lo que ha conducido a compuestos altamente selectivos por uno u otro receptor.  hasta el momento no existen antecedentes en la literatura en que peque\u00f1as modificaciones estructurales en una misma mol\u00e9cula den lugar a derivados selectivos por el receptor 5-ht1a \u00f3 a1. Por otro lado, el an\u00e1lisis de los resultados obtenidos en los ensayos bioqu\u00edmicos y farmacol\u00f3gicos, junto a la informaci\u00f3n obtenida de la modelizaci\u00f3n molecular y de los experimentos de noe bidimensional, nos ha permitido postular la hip\u00f3tesis de la conformaci\u00f3n extendida como la bioactiva en este tipo de ligandos.  la validez de esta hip\u00f3tesis se ha confirmado con el dise\u00f1o y s\u00edntesis de nuevos an\u00e1logos restringidos. Los interesantes resultados obtenidos tienen una gran aplicabilidad terap\u00e9utica, por lo que el trabajo presentado re\u00fane todos los requisitos necesarios para su presentaci\u00f3n a tr\u00e1mite de lectura.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los requerimientos estericos de la parte no farmacoforica en la afinidad\/selecticidad por el receptor 5-ht 1a.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los requerimientos estericos de la parte no farmacoforica en la afinidad\/selecticidad por el receptor 5-ht 1a. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tandu K. Rovat Lucas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Morcillo Ortega M. Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Soto camara Jos\u00e9 Luis <\/li>\n<li>esther Fernandez velando (vocal)<\/li>\n<li> Fernandez de la pradilla roberto (vocal)<\/li>\n<li>paloma Ballesteros Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tandu K. Rovat Lucas La presente tesis doctoral titulada \u00abestudio de los requerimientos est\u00e9ricos de la parte [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17,416],"tags":[89009,87901,89010,2508,5614,182030],"class_list":["post-86806","post","type-post","status-publish","format-standard","hentry","category-quimica","category-quimica-organica","tag-esther-fernandez-velando","tag-fernandez-de-la-pradilla-roberto","tag-morcillo-ortega-m-jose","tag-paloma-ballesteros-garcia","tag-soto-camara-jose-luis","tag-tandu-k-rovat-lucas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86806"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86806\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}