{"id":86831,"date":"2000-06-10T00:00:00","date_gmt":"2000-06-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-toxicodermias\/"},"modified":"2000-06-10T00:00:00","modified_gmt":"2000-06-10T00:00:00","slug":"estudio-de-las-toxicodermias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-las-toxicodermias\/","title":{"rendered":"Estudio de las toxicodermias"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rosa Del Rey M. Pilar De La <\/strong><\/h2>\n<p>Las reacciones adversas a medicamentos son una patolog\u00eda habitual tanto en atenci\u00f3n primaria como en atenci\u00f3n hospitalaria. Se considera que las toxicodermias son la forma m\u00e1s frecuente de reacci\u00f3n adversas a f\u00e1rmacos, y aunque para su diagn\u00f3stico muchas veces es suficiente una historia detallada, el empleo de t\u00e9cnicas complementarias como la biopsia puede ser definitiva en el diang\u00f3stico.  en este contexto consideramos de inter\u00e9s el realizar un estudio de las toxicodermias por patrones cl\u00ednico-patol\u00f3gicos para encontrar aspectos epidemiol\u00f3gicos, cl\u00ednicos y morfol\u00f3gicos que permitan su mejor diagn\u00f3stico y una aproximaci\u00f3n a sus mecanismos patog\u00e9nciso.  el estudio lo realizamos revisando los casos de biopsia cut\u00e1nea remitidos al servicio de anatom\u00eda patol\u00f3gica, seleccionando los 95 que presentaron un diagn\u00f3stico cl\u00ednico-patol\u00f3gico de toxicodermia y en los que adem\u00e1s eera conocido el t\u00f3xico o t\u00f3xicos desencadenante de la reacci\u00f3n. Se estudi\u00f3 la historia cl\u00ednica recavando datos epidemiol\u00f3gicos y cl\u00ednicos, y se revisaron  todas las biopsias constatando los hechos morfol\u00f3gicos diferenciales que presentaban. Adem\u00e1s se realiz\u00f3 un estudio inmunohistoqu\u00edmico con cd4, cd8 y s100 para valorar la naturaleza y distribuci\u00f3n del infiltrado inflamatorio en los casos en los que el mismo era abundante.  encontramos una mayor afectaci\u00f3n de mujeres que de hombres, y destac\u00f3 la alta incidencia de t\u00f3xicos de origen no medicamentoso (&gt;10%), que presentaron mayor tendencia a producir reacciones espongi\u00f3ticas. Los t\u00f3xicos de origen farmacol\u00f3gico fueron muy variados y ocasionaron patrones muy diversos, independiente de la v\u00eda de administraci\u00f3n utilizada, aunque los f\u00e1rmacos depresores del snc mostraron mayor tendencia a producir pigmentaci\u00f3n cut\u00e1nea. adem\u00e1s, las reacciones suelen desencadenarse en las dos primeras semanas desde el inicio del tratamiento.  la correlaci\u00f3n cl\u00ednicopatol\u00f3gica es fundamental par<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las toxicodermias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las toxicodermias <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rosa Del Rey M. Pilar De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> De La Rosa Del Rey M\u00aa Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Nistal mart\u00edn de serrano <\/li>\n<li>Jes\u00fas Cuevas santos (vocal)<\/li>\n<li>Mar\u00eda no Casado jimenez (vocal)<\/li>\n<li>angel Simon merchan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Del Rey M. Pilar De La Las reacciones adversas a medicamentos son una patolog\u00eda habitual tanto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,52,156],"tags":[15584,182061,42326,14272,50786,182060],"class_list":["post-86831","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-histopatologia","category-patologia","tag-angel-simon-merchan","tag-de-la-rosa-del-rey-ma-pilar","tag-jesus-cuevas-santos","tag-manuel-nistal-martin-de-serrano","tag-maria-no-casado-jimenez","tag-rosa-del-rey-m-pilar-de-la"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86831"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86831\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}