{"id":86858,"date":"2000-09-10T00:00:00","date_gmt":"2000-09-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/vitamina-d-sintesis-de-analogos-de-la-1alfa-25-dihidroxi-19-nor-previtamina-d3-transformaciones-regioselectivas-enzimaticas-de-los-sintones-precursores-de-los-anillo-a\/"},"modified":"2000-09-10T00:00:00","modified_gmt":"2000-09-10T00:00:00","slug":"vitamina-d-sintesis-de-analogos-de-la-1alfa-25-dihidroxi-19-nor-previtamina-d3-transformaciones-regioselectivas-enzimaticas-de-los-sintones-precursores-de-los-anillo-a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/vitamina-d-sintesis-de-analogos-de-la-1alfa-25-dihidroxi-19-nor-previtamina-d3-transformaciones-regioselectivas-enzimaticas-de-los-sintones-precursores-de-los-anillo-a\/","title":{"rendered":"Vitamina d: sintesis de an\u00e1logos de la 1alfa 25-dihidroxi-19-nor-previtamina d3. transformaciones regioselectivas enzimaticas de los sintones precursores de los anillo a."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Diaz Sierra <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os se ha producido un desarrollo espectuacular en la investigaci\u00f3n sobre la vitamina d3 como consecuencia del descubrimeinto del importante papel que juega su forma hormonalmente activa, la 1a, 25-dihidroxivitamina d3, en la diferenciaci\u00f3n celular y en la transcripci\u00f3n gen\u00e9tica.  en esta memoria, estructurada en tres cap\u00edtulos, se ha llevado a cabo la s\u00edntesis de an\u00e1logos de la 1a,25-dihidroxi-19-nor-previtamina d3, derivados con potencial actividad terap\u00e9utica. Tambi\u00e9n se han realizado un estudio sobre la rgioselectividad de las reacciones enzim\u00e1ticas de acilaci\u00f3n y aloxicarbonilaci\u00f3n de los correspondientes sintones 19-nor anillos a.  en el primer cap\u00edtulo se ha dise\u00f1ado una estrategia sint\u00e9tica para la obtenci\u00f3nd el (-) 5-epi-siquimato de meteilo, que constituye una excelente altenativa a las descritas enla bilbiograf\u00eda. Haciendo uso de la verstilidad del proceso se sintetiza por pirmera vez, el meso-5-epi-quintao de metilo. adem\u00e1s de su importancia intr\u00ednseca en el estudio de distintos procesos metab\u00f3licos, dada su alta funcionalidad pueden ser usados como materiales de partida en la s\u00edntesis de otros productos naturales, como se ver\u00e1 en el siguiente cap\u00edtulo. Los resultados obtenidos se encuentran recogidos en la publicaci\u00f3n.  \u00abnew and efficiente enantiospecific synthesis of (-)-methyl 5-epi-shinkimate and methy1  meso-5-epi-quinate from (-) qunic acid\u00bb s. Fern\u00e1ndez, m. D\u00edaz, m.Ferrero y v.Gotor tetrahed lett. 1997, 38,5225-5228.  con el fin de estudiar la influencia de la forma prvitamina en los efectos biol\u00f3gicos asociados a la vitamina d3, en el segundo cap\u00edtulo se aborda la s\u00edntesis de los extereois\u00f3meros en el anillo a de la 1a, 25-dihidroxi-19-nor-previtamina d3. En primer lugar se realiza la obtenci\u00f3n de los precursores adecuados del anillo a utilizando un proceso divergente que tiene como punto d epartida el \u00e1cido (-) qu\u00ednico, un producto natural de gran abundancia y baj<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Vitamina d: sintesis de an\u00e1logos de la 1alfa 25-dihidroxi-19-nor-previtamina d3. transformaciones regioselectivas enzimaticas de los sintones precursores de los anillo a.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Vitamina d: sintesis de an\u00e1logos de la 1alfa 25-dihidroxi-19-nor-previtamina d3. transformaciones regioselectivas enzimaticas de los sintones precursores de los anillo a. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Diaz Sierra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Gotor Santamar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marcial Moreno ma\u00f1as <\/li>\n<li>joaquin Plumet ortega (vocal)<\/li>\n<li>Antonio Galindo brito (vocal)<\/li>\n<li>Rafael Pedrosa sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Diaz Sierra En los \u00faltimos a\u00f1os se ha producido un desarrollo espectuacular en la investigaci\u00f3n sobre 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