{"id":86870,"date":"2000-10-10T00:00:00","date_gmt":"2000-10-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reordenamiento-secundario-de-la-cadena-lamda-de-celulas-b-perifericas-humanas-productoras-de-un-anticuerpo-antiislote-pancreatico-igm\/"},"modified":"2000-10-10T00:00:00","modified_gmt":"2000-10-10T00:00:00","slug":"reordenamiento-secundario-de-la-cadena-lamda-de-celulas-b-perifericas-humanas-productoras-de-un-anticuerpo-antiislote-pancreatico-igm","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/reordenamiento-secundario-de-la-cadena-lamda-de-celulas-b-perifericas-humanas-productoras-de-un-anticuerpo-antiislote-pancreatico-igm\/","title":{"rendered":"Reordenamiento secundario de la cadena lamda de celulas b perifericas humanas productoras de un anticuerpo antiislote pancreatico igm."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Benito Gonzalez <\/strong><\/h2>\n<p>Los reordeamientos secundarios (rs) en la regi\u00f3n variable de las inmunoglobulinas (lgs)y principalmente en el locus de las cadenas ligeras, se sabia que ocurrian solamente en la medula, en la superficie de las igm (slgm+) de las celulas b inmaduras, como un mecanismo de tolerancia central. Pero recientemente se ha encontrado que esto tambien ocurre en algunas celulas b maduras activadas del centro germinal, que podr\u00eda ser utilizado como un mecanismo de selecci\u00f3n negativa de celulas b autorreactivas resultado de hipermutaciones somaticas.  en la actualidad no hay datos de la existencia de un rs de las cadenas ligeras de la lg(igl) en celulas b perifericas humanas productoras de un anticuerpo asociado a una enfermedad autoinmune conocida. Nosotros mostramos un rs de la cadena     de un ig en una celula b transformada por ebv (mb91) productora de un anticuerpo igm    anti-islote pancreatico (ica) derivado de celulas b perifericas cd5- procedentes de un paciente diabetico tipo 1 al debut clinico de la enfermedad. Este clon mb91 que expresa rag1 y rag2, contiene un unico reordenamieto de la cadena pesada de la ig(igh r) (gb aj249378), sin embargo posee dos reordenamientos de la cadena ligera (ig   r):i) uno codifica el segmento v  1-4 unido a j  3-c  3, que codifica las cadenas   del ica-igm   , con un patr\u00f3n minimo de hipermutaciones som\u00e1ticas (gb aj249377), ii) el otro usa el segmento g\u00e9nico v 4-1 tambien unido a j 3-c 3, el cual contiene \u00abstop codons\u00bb que determinan la perdida de producci\u00f3n de ica-igm   (gb aj249379), y provocan la detenci\u00f3n del crecimiento de las celulas mb91, dado lugar a su muerte celular.  la idea de que el rs aberrante es el v 4-1y que reemplace el original v 1-4, anulando la s\u00edntesis de la cadena   y por tanto la imposibilidad de sintesis de una igm completa queda corroborado por:  1)el pl te\u00f3rico de las cadenas   del ica-igm   del clon mb91 homologo al v  1-4- j  3- c 3, es el m\u00e1s semejante al unico pl h<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reordenamiento secundario de la cadena lamda de celulas b perifericas humanas productoras de un anticuerpo antiislote pancreatico igm.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reordenamiento secundario de la cadena lamda de celulas b perifericas humanas productoras de un anticuerpo antiislote pancreatico igm. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Benito Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Gomis De Barbar?<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Pujol borrell <\/li>\n<li>pablo Engel rocamora (vocal)<\/li>\n<li>enric Vilardell latorre (vocal)<\/li>\n<li>margarida Castell escuer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Benito Gonzalez Los reordeamientos secundarios (rs) en la regi\u00f3n variable de las inmunoglobulinas (lgs)y principalmente en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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