{"id":86924,"date":"2018-03-10T00:11:38","date_gmt":"2018-03-10T00:11:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-la-glicoproteina-p-metalotioneina-proteina-p53-y-proteina-nm23-en-el-carcinoma-ductal-infiltrante-de-la-mama\/"},"modified":"2018-03-10T00:11:38","modified_gmt":"2018-03-10T00:11:38","slug":"expresion-de-la-glicoproteina-p-metalotioneina-proteina-p53-y-proteina-nm23-en-el-carcinoma-ductal-infiltrante-de-la-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-de-la-glicoproteina-p-metalotioneina-proteina-p53-y-proteina-nm23-en-el-carcinoma-ductal-infiltrante-de-la-mama\/","title":{"rendered":"Expresion de la glicoproteina p, metalotioneina, proteina p53 y proteina nm23 en el carcinoma ductal infiltrante de la mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Campora Jos\u00e9 Javier <\/strong><\/h2>\n<p>El cancer de mama es el tumor maligno mas frecuente en la mujer. A pesar de los continuos trabajos de investigaci\u00f3n, y de los esfuerzos dedicados a su diagnostico precoz, aun no se ha conseguido mejorar de forma significativa, la supervivencia global de los pacientes. El estadio ganglionar, el grado histol\u00f3gico, y el tama\u00f1o tumoral son factores pronosticos utiles pero insuficientes.  en el presente trabajo,hemos investigado la expresi\u00f3n inmunohistoquimica de proteinas producidas por las celulas tumorales que pueden influir notablemente en la respuesta a la quimioterapia, tales como la glicoproteina p, la proteina p53, y la metalotioneina. Asi mismo, tambien hemos estudiado la expresion de la proteina nm23, que ha sido relacionada en diversos tipos de tumores, incluidos los de mama, con la capacidad para producir metastasis. El material de estudio, lo componen 72 casos de carcinoma ductal infiltrante de la mama del tipo nos. Diagnosticados entre 1988 y 1993. Todos los tumores procedian de mastectomia radical con paquete ganglionar. Se recogieron en cada caso los datos clinicos mas representativos que incluyeron la evolucion clinica, siempre, distinguiendo entre intervalo libre de la enfermedad y supervivencia global. Los marcadores inmunohistoquimicos se determinaron seg\u00fan el metodo de la streptavidina-biotina y se cuantificaron como negativo (-), positivo debil (+), positivo moderado (++), y positivo fuerte (+++). el estudio estadistico incluyo las pruebas de krustal-wallis, chi-cuadrado, analisis multivariante de regresion logistica y analisis de supervivencia seg\u00fan el modelo de cox. Se encontro asociacion estadistica entre muerte por enfermedad, presencia de metastasis o de recidiva y grado histologico (p=0,001) e indice de mitosis (p=0,005). Asimismo, y se encontro asociacion entre indice de proliferacion seg\u00fan ki67, presencia de receptores estrogenicos, y expresion de p53 con grado histologico y tama\u00f1o tumoral. La expresion de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de la glicoproteina p, metalotioneina, proteina p53 y proteina nm23 en el carcinoma ductal infiltrante de la mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de la glicoproteina p, metalotioneina, proteina p53 y proteina nm23 en el carcinoma ductal infiltrante de la mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Campora Jos\u00e9 Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eugenio Arevalo Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda no Toro rojas <\/li>\n<li>Juan  Jos\u00e9 Sanchez carrillo (vocal)<\/li>\n<li>Jos\u00e9 ram\u00f3n Armas padr\u00f3n (vocal)<\/li>\n<li>alfredo Matilla vicente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Campora Jos\u00e9 Javier El cancer de mama es el tumor maligno mas frecuente en la mujer. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,9,973,156],"tags":[7890,2281,182189,11083,26540,20751],"class_list":["post-86924","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-medicas","category-cordoba","category-patologia","tag-alfredo-matilla-vicente","tag-eugenio-arevalo-jimenez","tag-gonzalez-campora-jose-javier","tag-jose-ramon-armas-padron","tag-juan-jose-sanchez-carrillo","tag-maria-no-toro-rojas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=86924"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/86924\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=86924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=86924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=86924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}