{"id":87006,"date":"2018-03-10T00:11:43","date_gmt":"2018-03-10T00:11:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-mediante-citometria-de-flujo-del-inmunofenotipo-de-los-mastocitos-humanos-de-medula-osea-enl-as-mastocitosis-sistemicas-del-adulto\/"},"modified":"2018-03-10T00:11:43","modified_gmt":"2018-03-10T00:11:43","slug":"estudio-mediante-citometria-de-flujo-del-inmunofenotipo-de-los-mastocitos-humanos-de-medula-osea-enl-as-mastocitosis-sistemicas-del-adulto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-mediante-citometria-de-flujo-del-inmunofenotipo-de-los-mastocitos-humanos-de-medula-osea-enl-as-mastocitosis-sistemicas-del-adulto\/","title":{"rendered":"Estudio mediante citometria de flujo del inmunofenotipo de los mastocitos humanos de m\u00e9dula \u00f3sea enl as mastocitosis sist\u00e9micas del adulto"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  D\u00edaz De Agust\u00edn Beatriz <\/strong><\/h2>\n<p>El objetivo principal de esta tesis ha sido comprobar el valor diagn\u00f3stico del inmunofenotipo de los mastocitos de m\u00e9dula \u00f3sea por citometr\u00eda de flujo en pacientes diagn\u00f3sticados de mastocitosis sist\u00e9mica. Se han estudiado un total de 21 pacientes diagnosticados de mastocitosis sist\u00e9mica indolente, 3 mastocitosis sist\u00e9micas agresivas, 2 mastocitosis malignas y 19 individuos sanos.  los resultados revelan que los mastocitosis medulares de las mastocitosis sist\u00e9micas indolentes poseen unas caracter\u00edsticas de dispersi\u00f3n de la luz, as\u00ed como, autofluorescencia superior a la de los mastocitos normales. Su porcentaje es significativamente mayor que el hallado en la m\u00e9dula \u00f3sea de sujetos normales. En las mastocitosis sist\u00e9micas agresivas y, especialmente, en las mastocitosis malignas, el porcentaje de mastocitos es m\u00e1s alto que en  las formas indolentes.  desde un punto de vista inmunofenot\u00edpico, los resultados m\u00e1s importantes son la expresi\u00f3n constante de los ant\u00edgenos cd2, cd25 y cd35 en los mastocitos de mastocitosis, mol\u00e9culas que est\u00e1n ausentes en los mastocitos normales, junto con la sobreexpresi\u00f3n de los ant\u00edgenos asociados a la activaci\u00f3n celular cd35, cd63 y cd69. Los mastocitos medulares de las mastocitosis sist\u00e9micas presentan cambios en su estado de actuaci\u00f3n y adhesi\u00f3n respecto a los normales.  el inmunofenotipo de los mastocitos de las mastocitosis agresivas y malignas es similar al descrito en las formas indolentes.  en conclusi\u00f3n, la citometr\u00eda de flujo permite la identificaci\u00f3n, el recuento y la caracterizaci\u00f3n inmunofenot\u00edpica de los mastocitos de m\u00e9dula \u00f3sea y debe ser incluida como una t\u00e9cnica de utilidad diagn\u00f3stica junto con los estudios histol\u00f3gicos, inmunohistoqu\u00edmicos y cl\u00ednicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio mediante citometria de flujo del inmunofenotipo de los mastocitos humanos de m\u00e9dula \u00f3sea enl as mastocitosis sist\u00e9micas del adulto<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio mediante citometria de flujo del inmunofenotipo de los mastocitos humanos de m\u00e9dula \u00f3sea enl as mastocitosis sist\u00e9micas del adulto <\/li>\n<li><strong>Autor:<\/strong>\u00a0  D\u00edaz De Agust\u00edn Beatriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Escribano Mora<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Luque cabrera <\/li>\n<li>teresa Montero vega (vocal)<\/li>\n<li>Jos\u00e9 Alberto Orfao de matos correia e vale (vocal)<\/li>\n<li> P\u00e9rez de oteyza Jaime (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de D\u00edaz De Agust\u00edn Beatriz El objetivo principal de esta tesis ha sido comprobar el valor diagn\u00f3stico del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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