{"id":87009,"date":"2018-03-10T00:11:43","date_gmt":"2018-03-10T00:11:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/descripcion-mediante-modelos-farmacocineticos-farmacodinamicos-del-efecto-antipiretico-y-antiinflamatorio-del-naproxeno-en-rata\/"},"modified":"2018-03-10T00:11:43","modified_gmt":"2018-03-10T00:11:43","slug":"descripcion-mediante-modelos-farmacocineticos-farmacodinamicos-del-efecto-antipiretico-y-antiinflamatorio-del-naproxeno-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/descripcion-mediante-modelos-farmacocineticos-farmacodinamicos-del-efecto-antipiretico-y-antiinflamatorio-del-naproxeno-en-rata\/","title":{"rendered":"Descripci\u00f3n mediante modelos farmacocin\u00e9ticos\/farmacodin\u00e1micos del efecto antipir\u00e9tico y antiinflamatorio del naproxeno en rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mariona Josa Albi\u00f1ana <\/strong><\/h2>\n<p>El objetivo del presente trabajo ha sido desarrollar un modelo farmacocin\u00e9tico\/farmacodin\u00e1micos (pk\/pd) para describir el curso temporal \u00abin vivo\u00bb, del efecto antipir\u00e9tico y anti-inflamatorio del naproxeno estimando sus par\u00e1metros farmacodin\u00e1micos.  estudio antipir\u00e9tico  una dosis de 0,1 mg\/kg de lipopolisac\u00e1rido de e. Coli (0111:b4) (lps) se inyect\u00f3 i.P. A ratas saludables, midiendo a lo largo del estudio la temperatura recta. La temperatura m\u00e1xima media (38,5 \u00c2\u00bac) ocurri\u00f3 a las 5,5 h tras la inyecci\u00f3n del lps. Dos grupos adicionales de ratas recibieron una sola dosis (7 mg\/kg) de s-naproxeno administrado en infusiones i.V. de 15 \u00f3 30 min. Ambas infusiones empezaron en el momento de fiebre m\u00e1xima. en un cuarto grupo una sola dosis (7 mg\/kg) de s-naproxeno se administr\u00f3 en infusi\u00f3n i.V. De 15 min 3 h tras la inyecci\u00f3n del lps.  estudio anti-inflamatorio  una dosis s.C. Al 1% de carragenina se inyect\u00f3 en la pata posterior de un grupo de ratas, midiendo mediante pletismograf\u00eda el aumento temporal de volumen debido a la respuesta inflamatoria. La m\u00e1xima diferencia de volumen alcanzada (46,22%) ocurri\u00f3 a las 3 horas tras la inyecci\u00f3n de la caragenina. Tres grupos adicionales de rstas recibieron dosis orales de 1.7,3.2 y 10 mg\/kg de naproxeno simult\u00e1neamente a la inyecci\u00f3n de la carrageina. se observ\u00f3 un retraso dosis-dependiente en la aparici\u00f3n de la respuesta inflamatoria. Sin embargo tras un cierto tiempo, la inflamaci\u00f3n aument\u00f3 hasta valores incluso superiores a los hallados en el grupo control.  en ambos estudios se obtuvieron simult\u00e1neamente medidas de concentraciones de f\u00e1rmaco en plasma y respuesta farmacodin\u00e1mica.  estudio pk\/pd  en ambos casos se usaron modelos de respuetas indirectas. El modelo propuesto para describir simult\u00e1neamente todos los resultados de la fiebre tiene los rasgo siguientes:  (i) antes de la inyecci\u00f3n del lps, el grado de fibre es fruto del balance entre la s\u00edntesis (ksi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Descripci\u00f3n mediante modelos farmacocin\u00e9ticos\/farmacodin\u00e1micos del efecto antipir\u00e9tico y antiinflamatorio del naproxeno en rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Descripci\u00f3n mediante modelos farmacocin\u00e9ticos\/farmacodin\u00e1micos del efecto antipir\u00e9tico y antiinflamatorio del naproxeno en rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mariona Josa Albi\u00f1ana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Fernandez De Troconiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>alicia Rodriguez gascon (vocal)<\/li>\n<li>carmelo Aguirre g\u00f3mez (vocal)<\/li>\n<li>Mar\u00eda del carmen Dios vi\u00e9itez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mariona Josa Albi\u00f1ana El objetivo del presente trabajo ha sido desarrollar un modelo farmacocin\u00e9tico\/farmacodin\u00e1micos (pk\/pd) para describir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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