{"id":87016,"date":"2018-03-10T00:11:43","date_gmt":"2018-03-10T00:11:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-de-la-epilepsia-farmacorresistente-mediante-aministracion-in-situ-de-anticonvulsivantes-en-el-snc-en-el-modelo-de-epilepsia-por-kindling-amigdalar-en-la-rata\/"},"modified":"2018-03-10T00:11:43","modified_gmt":"2018-03-10T00:11:43","slug":"tratamiento-de-la-epilepsia-farmacorresistente-mediante-aministracion-in-situ-de-anticonvulsivantes-en-el-snc-en-el-modelo-de-epilepsia-por-kindling-amigdalar-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-de-la-epilepsia-farmacorresistente-mediante-aministracion-in-situ-de-anticonvulsivantes-en-el-snc-en-el-modelo-de-epilepsia-por-kindling-amigdalar-en-la-rata\/","title":{"rendered":"Tratamiento de la epilepsia farmacorresistente mediante aministraci\u00f3n \u00abin situ\u00bb de anticonvulsivantes en el snc en el modelo de epilepsia por kindling amigdalar en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Ortiz Sanchez <\/strong><\/h2>\n<p>Despu\u00e9s del ictus, la epilepsia es la enfermedad neurol\u00f3gica m\u00e1s frecuente.Aunque actualmente cuenta con importantes tratamientos farmacol\u00f3gicos que consiguen controlar las crisis, un 20% de los pacientes no responden a dicho tratamietno, consituyendo el grupo de epilepsias farmacorresisntes, candidatos al tratamiento quir\u00fargico. Debido a que el tratamiento quir\u00fargico no se puede aplicar a todos los pacientes y presenta importantes secuelas, resulta de gran importancia la b\u00fasqueda de alternativas terapeuticas. En nuestro laboratorio hemos aplicado un antiepil\u00e9ptico nuevo, la gabapentina, con un \u00edndice de respuesta de un 30% cuando se administra por via oral a pacientes epilepticos, por via intracerebroventricular conla hipotesis de trabajo, de que esta forma de adminsitraci\u00f3n, al evitar las barreras naturales de difusi\u00f3n de medicamentos, seria m\u00e1s efectiva que la adminsitraci\u00f3n por via intraperitoneal (equivalente de la via intravenosa).  para comporbar esta hip\u00f3tesis se ha utilizado el modelo de epilepsia farmacorresistente del kindling amigdalar en la rata wistar macho.  la gabapentina se administr\u00f3 a un grupo de animales, que presentaban ciris convulsivas seg\u00fan el modelo del \u00ab\u00bbkindling\u00bb\u00bb, por v\u00eda intraperitoneal comprbando los efectos sobre los estadios de racine (intensidad de crisis) clase i, ii, iii,iv y v antes y despu\u00e9s del tratamiento con cuatro dosis, 100,200,300 y 500 mgr\/kg.  en una segunda etapa se adminsitr\u00f3 a dos grupos m\u00e1s, en el primero de ellos se utiliz\u00f3 la via intracerebroventiruclar aguda \u00ab\u00bben bolo (a las dosis de 750,975 y 1200 ugr) y en el otro la v\u00eda intracerebroventricular cr\u00f3nica ( a las dosis de 25 y 50 ugr\/ul de 7 d\u00edas de duraci\u00f3n). Ambos grupos estaban represenados por dos grupos control a los que se les administsr\u00f3 suero salino isot\u00f3nico con cada una de las dosis empleadas.  las variables analizadas en el grupo de la adminsitraci\u00f3n aguda fueron la intensidad y la duraci\u00f3n de la cr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento de la epilepsia farmacorresistente mediante aministraci\u00f3n \u00abin situ\u00bb de anticonvulsivantes en el snc en el modelo de epilepsia por kindling amigdalar en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento de la epilepsia farmacorresistente mediante aministraci\u00f3n \u00abin situ\u00bb de anticonvulsivantes en el snc en el modelo de epilepsia por kindling amigdalar en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Ortiz Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Barcia Albacar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Barcia salorio Juan  Luis <\/li>\n<li>jer\u00f3nimo Sancho rieger (vocal)<\/li>\n<li>enrique domingo Guijarro estelles (vocal)<\/li>\n<li>Manuel Alos almi\u00f1ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Ortiz Sanchez Despu\u00e9s del ictus, la epilepsia es la enfermedad neurol\u00f3gica m\u00e1s frecuente.Aunque actualmente cuenta con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,392],"tags":[11847,78821,19429,104078,27362,182334],"class_list":["post-87016","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-neurocirugia","tag-barcia-salorio-juan-luis","tag-enrique-domingo-guijarro-estelles","tag-jeronimo-sancho-rieger","tag-juan-antonio-barcia-albacar","tag-manuel-alos-alminana","tag-pedro-ortiz-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87016"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87016\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}