{"id":87018,"date":"2018-03-10T00:11:43","date_gmt":"2018-03-10T00:11:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ontogenesis-y-factores-de-regulacion-de-la-expresion-genica-de-la-leptina-y-las-protea%c2%adnas-desacoplantes\/"},"modified":"2018-03-10T00:11:43","modified_gmt":"2018-03-10T00:11:43","slug":"ontogenesis-y-factores-de-regulacion-de-la-expresion-genica-de-la-leptina-y-las-protea%c2%adnas-desacoplantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/ontogenesis-y-factores-de-regulacion-de-la-expresion-genica-de-la-leptina-y-las-protea%c2%adnas-desacoplantes\/","title":{"rendered":"Ontog\u00e9nesis y factores de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de la leptina y las prote\u00ednas desacoplantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Oliver Vara <\/strong><\/h2>\n<p>Las bases moleculares del sistema fisiol\u00f3gico de regulaci\u00f3n del peso corporal han sido objeto de un intenso estudio en los \u00faltimos a\u00f1os. En diciembre d e1994, el descubrimiento de la leptina, una hormona producida por tejido adiposo que refleja los niveles de grasa corporal y que forma parte del sistema de control de la ingesta, revolucion\u00f3 la invaestigaci\u00f3n de la obesidad. Hoy en d\u00eda se sabe que la leptina es secretada no s\u00f3lo por el tejido adiposo y que es una hormona con funciones m\u00e1s amplias que la de intervenir en el control de la homeostasis energ\u00e9tica.  la regulaci\u00f3n de la eficiencia energ\u00e9tica en las mitocondrias es otro punto de inter\u00e9s. En este sentido, el descubrimiento de nuevas prot\u00e9inas desacoplantes (ucos), con un patr\u00f3n de distribuci\u00f3n tisular m\u00e1s amplio que el de la bien conocidad termogenina o ucp1 del tam, y su psoble papel termog\u00e9nico, ha abierto nuevas posibilidades a la hora de considerar el control de la homeostasis energ\u00e9tica. Interesantemente, la leptina y las ucps est\u00e1n intrrelacionadas y comparten mecasnimos reguladores comunes. la leptina estimula el sns, que es el principal regulador de la termog\u00e9nesis en el tam,y es capaz de estimular, adem\u00e1s, la s\u00edntesis de ucps. Por otra parte, esta estimulaci\u00f3n del sns produce una retro-inhibici\u00f3n den la expresi\u00f3n de leptina.  en esta tesis se ha estudiado los cambios que tienen lugar en la expresi\u00f3n de los genes de la leptina y de las ucps conla edad. De esta forma, se ha descrito que los distintos dep\u00f3sitos grasos presentan pautas de comportamiento diferentes en la expresi\u00f3n g\u00e9nica de la leptina durante el desarrollo. esto resulta de inter\u00e9s pues es precisamente la distribuci\u00f3n de la grasa corporal, y no la grasa total, la que se asocia m\u00e1s estrechamente a las complicciones m\u00e9dicas de la obsesidad. Debido a la descripci\u00f3n de la presencia de leptina esn est\u00f3mago y su probable funcionalidad en humanos, descrita recientemente en nuesro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ontog\u00e9nesis y factores de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de la leptina y las prote\u00ednas desacoplantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ontog\u00e9nesis y factores de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de la leptina y las prote\u00ednas desacoplantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Oliver Vara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Illes balears<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Andreu Palou Oliver<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cabo soler <\/li>\n<li>Mar\u00eda  cinta Blade segarra (vocal)<\/li>\n<li>saverio Cinti (vocal)<\/li>\n<li>Francisco Garcia palmer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Oliver Vara Las bases moleculares del sistema fisiol\u00f3gico de regulaci\u00f3n del peso corporal han sido objeto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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