{"id":87023,"date":"2018-03-10T00:11:43","date_gmt":"2018-03-10T00:11:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-moleculares-en-pacientes-con-hiperparatiroidismo-primario\/"},"modified":"2018-03-10T00:11:43","modified_gmt":"2018-03-10T00:11:43","slug":"alteraciones-moleculares-en-pacientes-con-hiperparatiroidismo-primario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-moleculares-en-pacientes-con-hiperparatiroidismo-primario\/","title":{"rendered":"Alteraciones moleculares en pacientes con hiperparatiroidismo primario"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Cristobal Lana <\/strong><\/h2>\n<p>El hiperparatiroidismo primario se demine como un exceso de secreci\u00f3n de hormona paratiroidea en ausencia de est\u00edmulos fisiol\u00f3gicos, apropiados, lo que ocasiona una hipercalcemia. En la mayor de los casos (80%), es originado por adenomas paratiroideos, tumores benignos, generalmente solitarios.  en la presente tesis doctoral, se ha llevadoa cabo un anal\u00edsis molecular e inmunohistoqu\u00edmico de la regulaci\u00f3n del ciclo celular en adenomas paratiroideos. desde el punto de vista inmonohistoqu\u00edmico, se ha observado que ki-67,p27kip1,mdm2 y p21waf1 pueden ser marcadores \u00fatiles para diferenciar adenomas de tejido paratiroideo normal. P27kip1 y mdm2 est\u00e1n inversamente correlacionados; mdm2 presenta valores m\u00e1ximos en tejido tumoral y m\u00ednimos en tejido normal mientras que con p27kip1 ocurre lo contrario.  la ciclina d1 muestra una expresi\u00f3n elevado en ambos tipos de tejidos pero al realizar un an\u00e1lisis molecular a nivel de adn y arn, se observ\u00f3 que s\u00f3lo un 12% presentaba amplificaci\u00f3n del gen de la ciclina d1 y un 8% mostraba niveles superiores de arnm de la ciclina d1 con respecto al de la ciclina d2, por lo que es valido pensar en la existencia de mecanismos alternativos que incrementen la expresi\u00f3n de la prote\u00edna(alteraciones en la degradaci\u00f3n del arnm, un procesamiento alternativo del arnm, implicaci\u00f3n de otros genes,etc).  el estudio del polimorfismo bsml del gen del receptor de la vitamina d demostr\u00f3 la existencia de un genotipo predominante, el heterocigoto(bb), representado en el 57% de los casos. Por otra parte,los pacientes con genotipo bb eran los que presentaban los tumores de mayor tama\u00f1o y peso.  estos hallazgos demuestran la presencia de alteraciones en las rutas de los genes supresores rb y p53 en adenomas paratiroideos, lo que resulta sorprendente al tratarse de un tumor de naturaleza benigna. De hecho, a\u00fan se desconoce la causa por la cual no se produce una transformaci\u00f3n maligna en la inmensa mayor\u00eda de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones moleculares en pacientes con hiperparatiroidismo primario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones moleculares en pacientes con hiperparatiroidismo primario <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Cristobal Lana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Men\u00e1rguez Palanca Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: hernando Enriqueta mu\u00f1iz <\/li>\n<li>Jos\u00e9 Mar\u00eda Rojas caba\u00f1eros (vocal)<\/li>\n<li>Manuel Serrano marug\u00e1n (vocal)<\/li>\n<li> Juan  Carlos Martinez monedero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Cristobal Lana El hiperparatiroidismo primario se demine como un exceso de secreci\u00f3n de hormona paratiroidea en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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