{"id":87032,"date":"2018-03-10T00:11:47","date_gmt":"2018-03-10T00:11:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-cardiaca-en-la-rata-espontaneamente-hipertensa-implicacion-del-sistema-renina-angiotensina\/"},"modified":"2018-03-10T00:11:47","modified_gmt":"2018-03-10T00:11:47","slug":"estudio-de-la-apoptosis-cardiaca-en-la-rata-espontaneamente-hipertensa-implicacion-del-sistema-renina-angiotensina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-apoptosis-cardiaca-en-la-rata-espontaneamente-hipertensa-implicacion-del-sistema-renina-angiotensina\/","title":{"rendered":"Estudio de la apoptosis cardiaca en la rata espontaneamente hipertensa. implicacion del sistema renina-angiotensina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Ravassa Albeniz <\/strong><\/h2>\n<p>Se ha demostrado que en el ventriculo izquierdo de la rata shr la apoptosis est\u00e1 aumentada. Este trabajo se ha realizado para investigar si los mecanismos reguladores de la apoptosis estan alterados en el ventriculo izquierdo de la rata shr y si la angiotensina ii(aii) modifica dichos mecanismos. el estudio se ha efectuado en el ventriculo izquierdo de ratas wky adultas, ratas shr adultas y ratas shr tratadas cronicamente con el bloqueante de los receptores at1 losartan. Adem\u00e1s, se han analizado los efectos de la aii en cardiomicitos aislados de ratas wky y shr adultas. Tras identificar in situ las celulas apoptoticas mediante la tecnica del tunel in vivo e in vitro, confirmando los resultados obtenidos in vitro mediante la detecci\u00f3n de anexina v, se midi\u00f3 la expresi\u00f3n de las proteinas bax-a,bcl-2,p53 y la activacion de la proteina caspasa-3 mediante western blot. La expresi\u00f3n del gen bax se determin\u00f3 mediante northern blot. En el estudio in vivo, las ratas shr mostraban un aumento (p&lt;0,05) de la apoptosis,de la cantidad de proteina bax-a(p&lt;0,05), y del indice de susceptibilidad a la apoptosis, de la cantidad de proteina bax-a(p&lt;0,05), y del indice de susceptibilidad a la apoptosis bax-a\/bcl-2(p&lt;0,05), comparadas con las ratas wky. Los valores de arnm del gen bax enlas ratas shr fueron similares a los de las ratas wky. Las ratas shr tratadas con losart\u00e1n mostraban valores normales de apoptosis, bax-a, bcl-2 y cociente bax-a\/bcl-2 y una disminuci\u00f3n en la expresi\u00f3n del arnm del gen bax. En el estudio in vitro, la aii provoc\u00f3 un aumento(p&lt;0,01) del indice apoptotico y de la expresi\u00f3n de la proteina bax-a en los cardiomiocitos extraidos de ambas cepas de ratas,siendo estos efectos mayores (p&lt;0,001) en las celulas extraidas de las ratas shr que en las extraidas de las ratas wky. El losartan (10-7 m) inhibi\u00f3 los efectos de la aii en ambas cepas de rata, mientras que la incubaci\u00f3n con pd123319(10-7 m) inhibi\u00f3 la ap<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis cardiaca en la rata espontaneamente hipertensa. implicacion del sistema renina-angiotensina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis cardiaca en la rata espontaneamente hipertensa. implicacion del sistema renina-angiotensina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Ravassa Albeniz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M.antonia Fortu\u00f1o Cebamanos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tomas Quesada perez <\/li>\n<li>Francisco Javier Salazar aparicio (vocal)<\/li>\n<li>Mar\u00eda pilar Sesma egozcue (vocal)<\/li>\n<li>Jos\u00e9 Antonio Paramo fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Ravassa Albeniz Se ha demostrado que en el ventriculo izquierdo de la rata shr la apoptosis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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