{"id":87104,"date":"2018-03-10T00:11:51","date_gmt":"2018-03-10T00:11:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-sintesis-de-factores-endoteliales-vasoactivos-por-la-matriz-extracelular-posibles-mecanismos-implicados\/"},"modified":"2018-03-10T00:11:51","modified_gmt":"2018-03-10T00:11:51","slug":"modulacion-de-la-sintesis-de-factores-endoteliales-vasoactivos-por-la-matriz-extracelular-posibles-mecanismos-implicados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-sintesis-de-factores-endoteliales-vasoactivos-por-la-matriz-extracelular-posibles-mecanismos-implicados\/","title":{"rendered":"Modulaci\u00f3n de la sintesis de factores endoteliales vasoactivos por la matriz extracelular. posibles mecanismos implicados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Gonz\u00e1lez Santiago <\/strong><\/h2>\n<p>La acumulaci\u00f3n de prote\u00ednas normales de la matriz extracelular y la aparici\u00f3n de col\u00e1genos inersticiales, principalmente col\u00e1geno tipo i, caracterizan patolog\u00edas vasculares como hipertensi\u00f3n, aterosclerosis y diabetes. Estudios previos sugieren que la matriz modula el fenotipo de las c\u00e9lulas. Sin embargo, apenas se ha analizado el efecto de la composici\u00f3n de la matriz sobre el comportamiento celular.  el objetivo de este trabajo fue analizar el papel del colageno i (col.L), principal componente de la matriz extracelular en situaciones patol\u00f3gicas, en la s\u00edntesis de los factores endoteliales vasoactivos \u00f3xido n\u00edtrico (no) y endotelina (et-1), as\u00ed como los posibles mecanismos implicados en dicha modulaci\u00f3n. Se cultivaron c\u00e9lulas endoteliales humanas de vena umbilical (huvec) en dos tipos de matrices: col.Lv y col.L y se estudi\u00f3 la expresi\u00f3n de preproendotelina-1, la s\u00edntesis de et y la enzima conversora de la et, paso limitante de este proceso. Respecto al no, se analizaron: la expresi\u00f3n y actividad de la \u00f3xido n\u00edtrico sintasa endotelial (enos), su promotor y la s\u00edntesis de no. En ambos casos, se profundiz\u00f3 en los mecanismos implicados en los efectos inducidos por el col\u00e1geno i, haciendo especial hincapi\u00e9 en las integrinas, proteina quinasas y el sistema de la llk.  nuestros resultados sugieren que en presencia de una matriz anormal se produce una mayor activaci\u00f3n del sistema vasconstrictor de la et, as\u00ed como un empeoramiento de la relajaci\u00f3n dependiente de endotelio, o lo que es lo mismo una disminuci\u00f3n de la s\u00edntesis de no, favoreciendo as\u00ed el mantenimiento y la progresi\u00f3n de las alteraciones hemodin\u00e1micas que tienen lugar en diversas lesiones vasculares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la sintesis de factores endoteliales vasoactivos por la matriz extracelular. posibles mecanismos implicados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la sintesis de factores endoteliales vasoactivos por la matriz extracelular. posibles mecanismos implicados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Gonz\u00e1lez Santiago <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/10\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Rodr\u00edguez Puyol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Egido de los rios <\/li>\n<li> La hera julia vicente (vocal)<\/li>\n<li>lisardo Boscat (vocal)<\/li>\n<li> Orte Martinez Luis Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Gonz\u00e1lez Santiago La acumulaci\u00f3n de prote\u00ednas normales de la matriz extracelular y la aparici\u00f3n de col\u00e1genos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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