{"id":87175,"date":"2000-03-11T00:00:00","date_gmt":"2000-03-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-una-proteina-celular-gip1-que-interacciona-con-la-replicasa-del-virus-tylcv\/"},"modified":"2000-03-11T00:00:00","modified_gmt":"2000-03-11T00:00:00","slug":"caracterizacion-de-una-proteina-celular-gip1-que-interacciona-con-la-replicasa-del-virus-tylcv","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-de-una-proteina-celular-gip1-que-interacciona-con-la-replicasa-del-virus-tylcv\/","title":{"rendered":"Caracterizacion de una proteina celular (gip1) que interacciona con la replicasa del virus tylcv."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Donoso Cuenca <\/strong><\/h2>\n<p>Los geminivirus son virus de plata con un genomio de dna circular de cadena sencilla, que contiene entre 6-8 genes. El gen rep es el \u00fanico gen viral esencial para su replicaci\u00f3n. Este gen codifica una prote\u00edna multifuncional que se une espec\u00edficamente al origen de replicaci\u00f3n viral.  la presencia de esta prote\u00edna en c\u00e9lulas vegetales induce la aparici\u00f3n de prote\u00ednas espec\u00edficas de fase s. Esta induci\u00f3n se asemeja a la que ocurre en algunos virus animales (adenovirus, poliomavirus.Etc.). Como en estos virus, la desregulaci\u00f3n del ciclo celular podr\u00eda implicar interacciones de la proteina rep con prote\u00ednas celulares implicadas en control del ciclo.  utilizando la t\u00e9cnica de two hybrid system, hemos aislado una prote\u00edna de s. Pombe que interacciona con prep, a la que hemos denominado gip1.  se ha llevado a cabo el estudio funcional del gen en s. Pombe, donde se ha visto que su deleci\u00f3n es leta. La construcci\u00f3n de un mutante condicional para este gen ha permitido hacer un an\u00e1lisis funcional de la prote\u00edna. mediante este an\u00e1lisis se ha observado que el mutante condicional, cultivado en condiciones de no expresi\u00f3n de gip1, presenta un bloqueo en la fase g1 y adem\u00e1s es incapaz de realizar citocinesis. Este fenotipo se corresponde con mutantes en la transici\u00f3n mitosis-interfase, tambi\u00e9n denominados sns(mutantes septados-no en fase s). Otra caracter\u00edstica del mutantes condicional es la presencia de un septo m\u00e1s grueso que el control. El an\u00e1lisis en detalle de la estructura del septo mediante microscop\u00eda electr\u00f3nica muestra esta anormalidad en la estructura del septo se manifiesta ya en los primeras etapas de su formaci\u00f3n. La estructura y localizaci\u00f3n de la actina no presenta, sin embargo, anormalidades. La b\u00faslqueda de hom\u00f3logos de este gen tanto inform\u00e1tica como f\u00edsicamente ha permitido concluir que el gen que codifica esta prote\u00edna est\u00e1 conservado en todos los eucariontes. Adem\u00e1s se ha comprobado que el g<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de una proteina celular (gip1) que interacciona con la replicasa del virus tylcv.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de una proteina celular (gip1) que interacciona con la replicasa del virus tylcv. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Donoso Cuenca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Rodr\u00edguez Bejarano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Jim\u00e9nez mart\u00ednez <\/li>\n<li> Aranda regules migual angel (vocal)<\/li>\n<li>sergio Moreno p\u00e9rez (vocal)<\/li>\n<li> Mu\u00f1oz centeno M\u00aa cruz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Donoso Cuenca Los geminivirus son virus de plata con un genomio de dna circular de cadena [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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