{"id":87203,"date":"2000-06-11T00:00:00","date_gmt":"2000-06-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-formulaciones-parenterales-de-anfotericina-b-para-el-tratamiento-de-micosis-sistemicas-en-pacientes-inmunodeprimidos\/"},"modified":"2000-06-11T00:00:00","modified_gmt":"2000-06-11T00:00:00","slug":"nuevas-formulaciones-parenterales-de-anfotericina-b-para-el-tratamiento-de-micosis-sistemicas-en-pacientes-inmunodeprimidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevas-formulaciones-parenterales-de-anfotericina-b-para-el-tratamiento-de-micosis-sistemicas-en-pacientes-inmunodeprimidos\/","title":{"rendered":"\u00abnuevas formulaciones parenterales de anfotericina b para el tratamiento de micosis sist\u00e9micas en pacientes inmunodeprimidos\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Moreno Santurino Marco Antonio <\/strong><\/h2>\n<p>Los objetivos de la presente tesis doctoral son el desarrollo y posterior evaluaci\u00f3n toxicol\u00f3gica de nuevas formulaciones parenterales de anfotericina b, destinadas al tratamiento de micosis sist\u00e9micas oportunistas frecuentemente asociadas a estados de inmunodepresi\u00f3n existentes en patolog\u00f1\u00edas tales como el sida y el c\u00e1ncer.  para cumplir los objetivos propuestos, se llevar\u00e1 a cabo el estudio de diversas car\u00e1cter\u00edsticas fisico-quimicas del f\u00e1rmaco as\u00ed como el dise\u00f1o de nuevas formas farmac\u00e9uticas paraentales (microemulsiones y emulsiones paraterales) que nos permitan vehiculizar el principio activo con mayor seguridad y eficacia que la formulaci\u00f3n convencional.  la toxicidad de los nuevos preparados se evaluar\u00e1 en animales de experimentaci\u00f3n(ratones albino macho cd-1) y se comparar\u00e1 con la toxicidad provocada por la formulaci\u00f3n convecional, que tambi\u00e9n ser\u00e1 desarrollada por nosotros a lo largo del estudio.  el estudio de las propiedades fisico-quimicas de la anfotericina b se llevar\u00e1 a cabo previa puesta a punto y validaci\u00f3n de dos t\u00e9cnicas instrumentales, espectrofotometr\u00eda uv-visible y hplc, que nos permitir\u00e1n el an\u00e1lisis cuantitativo y cualitativo del f\u00e1rmaco. A continuaci\u00f3n se formular\u00e1 el principio activo en forma de emulsi\u00f3n parenteral y de microemulsi\u00f3n, utilizando para el dise\u00f1o de estas \u00faltimas los diagramas de fases pseudo-ternarios.  para la caracterizaci\u00f3n de estos sitemas dispersos, realizaremos estudios de viscosidad, potencial z y espectroscop\u00eda de correlaci\u00f3n fot\u00f3nica, t\u00e9cnica muy \u00fatil y recomendable en la determinaci\u00f3n de tama\u00f1os de fase dispersa inferiores a 1 micr\u00f3metro.  finalmente, evaluaremos la estabilidad de los distintos preparados en diversas condiciones de temperatura y humedad relativa, estableciendo de este modo las condiciones \u00f3ptimas para su almacenamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abnuevas formulaciones parenterales de anfotericina b para el tratamiento de micosis sist\u00e9micas en pacientes inmunodeprimidos\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abnuevas formulaciones parenterales de anfotericina b para el tratamiento de micosis sist\u00e9micas en pacientes inmunodeprimidos\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Moreno Santurino Marco Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda De La Paloma Ballesteros Papantonakis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>alfonso Jes\u00fas Dominguez gil hurle (vocal)<\/li>\n<li> Elorza barroeta Mar\u00eda  de los angeles (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Moreno Santurino Marco Antonio Los objetivos de la presente tesis doctoral son el desarrollo y posterior evaluaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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