{"id":87210,"date":"2000-06-11T00:00:00","date_gmt":"2000-06-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-resistencia-a-quinolonas-en-cepas-clinicas-de-acinetobacter-baumannii\/"},"modified":"2000-06-11T00:00:00","modified_gmt":"2000-06-11T00:00:00","slug":"mecanismos-de-resistencia-a-quinolonas-en-cepas-clinicas-de-acinetobacter-baumannii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-de-resistencia-a-quinolonas-en-cepas-clinicas-de-acinetobacter-baumannii\/","title":{"rendered":"Mecanismos de resistencia a quinolonas en cepas clinicas de acinetobacter baumannii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Lopez Hernandez <\/strong><\/h2>\n<p>Se han estudiado los mecanismos de resistencia a quinolonas en 30 cepas cl\u00ednicas de a.Baumannii. La identificaci\u00f3n bioqu\u00edmica se realiz\u00f3 seg\u00fan el esquema de bouvet y grimont. Utilizando estos resultados las cepas se agruparon desde el punto de vista epidemiol\u00f3gico seg\u00fan el concepto de patr\u00f3n de crecimiento. La relaci\u00f3n epidemiol\u00f3gica tambi\u00e9n se estudio con las t\u00e9cnicas de rep-pcr t buotipia(bouvet y grimont). El agrupamiento de las cepas siguiendo el criterio de los patrones de creciiento present\u00f3 un poder de discriminaci\u00f3n mayor que la biotipia. El m\u00e9todo de rep-pcr fue el m\u00e9todo m\u00e1s sensible, r\u00e1pida y con mayor poder de discriminaci\u00f3n.  el estudio de los mecanismos de resistencia se centr\u00f3 en el estudio de mutaciones en genes (gyra,parc) que codifican topoisomerasas y en la detecci\u00f3n de sistemas de expulsi\u00f3n activa de quinolonas al exterior celular.  los m\u00e9todos utilizados en el estudio de mutaciones fueron:rflp-hingl, sscp y secuenciaci\u00f3n. Todas las cepas resistentes a ciprofloxacino presentaron mutaciones en ser83(gyra). La sustituci\u00f3n m\u00e1s frecuente fue ser83leu, aunque se encontr\u00f3  una mutaci\u00f3n no descrita antes de a.Baumannii:ser83ala. Las cepas con un nivel de resistencia m\u00e1s alto presentaron una mutaci\u00f3n adicional:ser80leu(parc).Tanto rflp-hinfi como sscp son t\u00e9cnicas r\u00e1pidas y fiables para la detecci\u00f3n de mutaciones en estas posiciones, pudiendo sscp diferenciar el tipo de sustituci\u00f3n.  la detecci\u00f3n de sistemas de expulsi\u00f3n activa se realiz\u00f3 con t\u00e9cnicas de acumulaci\u00f3n de antimicrobianos utilizando inhibidores metab\u00f3licos. No hubo relaci\u00f3n directa entre la concentraci\u00f3n intracelular de quinolona y el valor de cmi(concentraci\u00f3n m\u00ednima inhibitoria), lo que apoya la idea de que el nivel de resistencia est\u00e1 determinado fundamentalmente por alteraciones de las topoisomerasas. En los aislamientos cl\u00ednicos con mutaciones a nivel de gyra y parc se comprob\u00f3 la existencia de un sistema de elim<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de resistencia a quinolonas en cepas clinicas de acinetobacter baumannii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de resistencia a quinolonas en cepas clinicas de acinetobacter baumannii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Lopez Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Martinez Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>isabel Garcia luque (vocal)<\/li>\n<li> Borobio enciso m. victoria (vocal)<\/li>\n<li>Jes\u00fas Mart\u00ednez beltr\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Lopez Hernandez Se han estudiado los mecanismos de resistencia a quinolonas en 30 cepas cl\u00ednicas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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