{"id":87251,"date":"2000-09-11T00:00:00","date_gmt":"2000-09-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-la-morina-en-un-modelo-experimental-de-inflamacion-intestinal-en-ratas\/"},"modified":"2000-09-11T00:00:00","modified_gmt":"2000-09-11T00:00:00","slug":"estudio-del-efecto-de-la-morina-en-un-modelo-experimental-de-inflamacion-intestinal-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-de-la-morina-en-un-modelo-experimental-de-inflamacion-intestinal-en-ratas\/","title":{"rendered":"Estudio del efecto de la morina en un modelo experimental de inflamacion intestinal en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Coelho Bernardo Guerra Gerlane <\/strong><\/h2>\n<p>El objeto de \u00e9sta tesis doctoral es el estudio de la actividad antiinflamatoria de la morna frente a la inflamaci\u00f3n intestinal inducida por tnbs\/etanol en rata. Este agente produce un da\u00f1o en el colon que reproduce con bastante precisi\u00f3n el proceso inflamantorio intestinal en humanos (wallace, 1994). trabajos previos demuestran que la morina es un potente agente antioxidante (mora et al. 1990) y un inhibidor de la lipooxigenasa (baumann et al., 1980; nakadete et al., 1984; tanaka et al., 1999). Para llevar a cabo \u00e9ste trabajo hemos re alizado dos protocolos experimentales.  1- efecto preventivo frente a la inflamaci\u00f3n intestinal aguda inducida por 10 mg. De tnbs.  2- efecto regenerador de la mucosa intestinal frente a la inflamaci\u00f3n intestinal cr\u00f3nica inducida por 30mg de tnbs.  se estudiaron distintos par\u00e1metros:  1- par\u00e1metros generales: diarrea, adherencias y consumo de comida  2- par\u00e1metros macrosc\u00f3picos: idm y relaci\u00f3n p\/l  3- par\u00e1metros bioqu\u00edmicos: actividad mieloperoxidasa, niveles de malhonildialdeh\u00eddo, niveles de glutatio, il-1b,ltb4. Y niveles de citrulina.  podemos concluir que la morina presenta un efecto antiinflamatorio intestinal que se manifiesta por una actuaci\u00f3n sobre distintos mediadores implicados en el proceso inflamatorio y que se puede resumir:  &#8211; inhibici\u00f3n en la s\u00edntesis y\/o liberaci\u00f3n del ltb4.  &#8211; actividad antioxidante previniendo la generaci\u00f3n de radicales libres, tanto derivados del ox\u00edgeno como del nitr\u00f3geno, responsables de la fase inicial, as\u00ed como, de la cronificaci\u00f3n del proceso inflamatorio intestinal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de la morina en un modelo experimental de inflamacion intestinal en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de la morina en un modelo experimental de inflamacion intestinal en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Coelho Bernardo Guerra Gerlane <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zarzuelo Zurita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Jimenenz martin <\/li>\n<li>Jos\u00e9 pedro De la cruz cort\u00e9s (vocal)<\/li>\n<li>angel Concha lopez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Coelho Bernardo Guerra Gerlane El objeto de \u00e9sta tesis doctoral es el estudio de la actividad antiinflamatoria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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