{"id":87268,"date":"2000-10-11T00:00:00","date_gmt":"2000-10-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-interaccion-del-tercer-componente-del-sistema-del-complemento-con-la-region-fc-de-la-igg-humana\/"},"modified":"2000-10-11T00:00:00","modified_gmt":"2000-10-11T00:00:00","slug":"estudios-de-interaccion-del-tercer-componente-del-sistema-del-complemento-con-la-region-fc-de-la-igg-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudios-de-interaccion-del-tercer-componente-del-sistema-del-complemento-con-la-region-fc-de-la-igg-humana\/","title":{"rendered":"Estudios de interaccion del tercer componente del sistema del complemento con la region fc de la igg humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Pastor Vargas <\/strong><\/h2>\n<p>La interacci\u00f3n entre los complejos ant\u00edgeno-anticuerpo (inmunocomplejos, ic) y el tercer componente (c3) es uno de los pasos fundamnteales que conduce a la eliminaci\u00f3n del ant\u00edgeno. Adem\u00e1s, estos complejos c3-ic cumplen diversas funciones en la activaci\u00f3n y desarrollo de la respuesta inmune.  dada la importancia de esta interacci\u00f3n, se ha realizado una amplia investigaci\u00f3npara determinar la naturaleza de la uni\u00f3n y en ella se han descrito que, en la igh1 humana, tanto elfragmenteo fab como el fc est\u00e1n implicados en la luni\u00f3n con c3. Mientras la interacci\u00f3n c3-fab est\u00e1 bastante estudiada, la uni\u00f3n c3-fc ha sido objeto de un estudio menos exhaustivo.  el objetivo de este trabajo ha sido el estudio de la implicaci\u00f3n de los dominos ch2 y ch3 de la igg humana en la interacci\u00f3n con c3. Para ello se han generado un conjunto de anticuerpos que no unen c3 por la regi\u00f3n fab, por carecer del domino ch1, pero que mantienen su capacidad de activar c3. Adem\u00e1s, a estos anticuerpos les hemos introducido la secuencia especifica que reconocer el factor xa, tanto en la zona bisagra (\u00abhinge\u00bb) como en el interdomino ch2-ch3 de tal forma que, mediante digestiones dirigidas, podemos aislar el o los dominos implicados en la interacci\u00f3n con la mol\u00e9cular de c3b intacta. Los resultados obtenidos han permitido caracterizar la uni\u00f3n de c3 tanto al domino ch2 como al domino ch3.  la uni\u00f3n de c3 en el dominio ch2 se produce, en la regi\u00f3n bisagra (\u00abhinge\u00bb), concretamente en el p\u00e9ptido 219scdkthtcppcpapellggpsvflfppkpk248. Los candidatos m\u00e1s probables de esta regi\u00f3n lo constituyan los residuos 223thr y 225thr.  la uni\u00f3n de c3 en el domino ch3 se produce, muy probablemente, en el extremo carboxilo teminal, concretamente en el p\u00e9ptido 440solslspgk447. el candidato m\u00e1s probable de esta regi\u00f3n los constituye el residuo 447lys.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de interaccion del tercer componente del sistema del complemento con la region fc de la igg humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de interaccion del tercer componente del sistema del complemento con la region fc de la igg humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Pastor Vargas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vivanco Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 gregorio Gavilanes franco <\/li>\n<li>Santiago Rodriguez de cordoba (vocal)<\/li>\n<li> Anton calvo Luis c. (vocal)<\/li>\n<li>Javier Benedi benito (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Pastor Vargas La interacci\u00f3n entre los complejos ant\u00edgeno-anticuerpo (inmunocomplejos, ic) y el tercer componente (c3) es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2727,35,1737],"tags":[182738,79674,6523,19953,5832,15504],"class_list":["post-87268","post","type-post","status-publish","format-standard","hentry","category-anticuerpos","category-ciencias-de-la-vida","category-inmunologia","tag-anton-calvo-luis-c","tag-carlos-pastor-vargas","tag-fernando-vivanco-Martinez","tag-javier-benedi-benito","tag-jose-gregorio-gavilanes-franco","tag-santiago-rodriguez-de-cordoba"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87268"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87268\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}