{"id":87325,"date":"2018-03-10T00:12:04","date_gmt":"2018-03-10T00:12:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-expresion-de-moleculas-de-adhesion-endotelial-con-interleucina-1-en-el-curso-del-sindrome-de-disfuncion-organica-multiple-tras-una-agresion-endotoxica-experimental\/"},"modified":"2018-03-10T00:12:04","modified_gmt":"2018-03-10T00:12:04","slug":"modulacion-de-la-expresion-de-moleculas-de-adhesion-endotelial-con-interleucina-1-en-el-curso-del-sindrome-de-disfuncion-organica-multiple-tras-una-agresion-endotoxica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-expresion-de-moleculas-de-adhesion-endotelial-con-interleucina-1-en-el-curso-del-sindrome-de-disfuncion-organica-multiple-tras-una-agresion-endotoxica-experimental\/","title":{"rendered":"Modulaci\u00f3n de la expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n endotelial con interleucina-1 en el curso del sindrome de disfunci\u00f3n org\u00e1nica m\u00faltiple tras una agresi\u00f3n endot\u00f3xica experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  T\u00e9llez Gil Luis Eduardo <\/strong><\/h2>\n<p>La expresion de mol\u00e9culas de adhesi\u00f3n elam-1, icam-1 y vcam-1 sobre el endotelio vascular de \u00f3rganos que son afectados en el shock endot\u00f3xico son fundamentales en el da\u00f1o tisularque se produce como consecuencia del aumento de la adhesi\u00f3n de leucocitos al endotelio, provoc\u00e1ndose un mayor infiltrado neutrof\u00edlico  y liberaci\u00f3n de radicales libres, que mediante un fen\u00f3meno de peroxidaci\u00f3n lip\u00eddica provocan el da\u00f1o celular irreversible. se ha observado que el pretratamiento con bajas dosis de interleucina-1 es capaz de producir un fen\u00f3meno de tolerancia a la endotoxina, aumentando la supervivencia en modelos experimentales de shock endotoxico. En este trabajo experimental hemos determinado que este efecto se relaciona con la disminuci\u00f3n significativa en la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n endotelial tanto a nivel tisular como de sus fases solubles, efecto debido en parte a la disminuci\u00f3n de mediadores proinflamatorios, provoc\u00e1ndose, el descenso en los niveles del infiltrado leucocitario y del da\u00f1o tisular, as\u00ed como el aumento de la supervivencia tras la agresi\u00f3n con la endotoxina y todo ello como consecuencia de la inyecci\u00f3n previa de bajas dosis de interleucina 1 beta que sensibiliza previamente a las c\u00e9lulas inmunologicamente competentes en la producci\u00f3n de la citoquinas proinflamatorias causando la disminuci\u00f3n en su s\u00edntesis.  de igual manera, hemos observado un elevado grado de asociaci\u00f3n entre los niveles circulantes de las citocinas tnf alfa il-1 e il-6 y la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n endotelial y de estas \u00faltimas y la cantidad de linfocitos y monogranulocitos circulantes en sangre perif\u00e9rica, determin\u00e1ndose su importancia en el proceso de marginaci\u00f3n y min\u00e1ndose su importancia en el proceso de marginaci\u00f3n y migraci\u00f3n leucocitaria, procesos que como hemos concluido, disminuyen con el pretratamiento con interleucina 1 beta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n endotelial con interleucina-1 en el curso del sindrome de disfunci\u00f3n org\u00e1nica m\u00faltiple tras una agresi\u00f3n endot\u00f3xica experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n endotelial con interleucina-1 en el curso del sindrome de disfunci\u00f3n org\u00e1nica m\u00faltiple tras una agresi\u00f3n endot\u00f3xica experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  T\u00e9llez Gil Luis Eduardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Ferr\u00f3n Orihuela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Garcia gil <\/li>\n<li>Jos\u00e9 Juan Gaforio Martinez (vocal)<\/li>\n<li>federico Garrido torres-puchol (vocal)<\/li>\n<li>Mar\u00eda  monica De la fuente del rey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de T\u00e9llez Gil Luis Eduardo La expresion de mol\u00e9culas de adhesi\u00f3n elam-1, icam-1 y vcam-1 sobre el endotelio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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