{"id":87355,"date":"2018-03-10T00:12:09","date_gmt":"2018-03-10T00:12:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-funcional-de-protea%c2%adnas-antioxidantes-en-el-extracto-excretor-secretor-de-fasciola-hepatica\/"},"modified":"2018-03-10T00:12:09","modified_gmt":"2018-03-10T00:12:09","slug":"identificacion-y-caracterizacion-funcional-de-protea%c2%adnas-antioxidantes-en-el-extracto-excretor-secretor-de-fasciola-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/identificacion-y-caracterizacion-funcional-de-protea%c2%adnas-antioxidantes-en-el-extracto-excretor-secretor-de-fasciola-hepatica\/","title":{"rendered":"\u00abidentificaci\u00f3n y caracterizaci\u00f3n funcional de prote\u00ednas antioxidantes en el extracto excretor-secretor de fasciola hepatica\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Salazar Calderon M. Elisa <\/strong><\/h2>\n<p>Mediante el uso de sueros de conejos inmunizados con el extracto excretor-secretor de fasciola hepatica se identificaron varios genes de una genoteca construida en el fago   gt11.  estos cdnas fueron caracterizados por determinaci\u00f3n de su secuencia de nucle\u00f3tidos y la b\u00fasqueda en bancos de datos de secuencias hom\u00f3logas. Las regiones de los cdnas codificadoras de prote\u00ednas fueron clonadas en los vectores de expresi\u00f3n de escherichia coli apropiados para producir las prote\u00ednas en cantidad suficiente sin tener necesidad de purificarla del par\u00e1sito. Estas prote\u00ednas heter\u00f3logas fueron empleadas para producir anticuerpos en conejos y as\u00ed identificar a las proteinas nativas en el extracto excretor-secretor. las prote\u00ednas producidas fueron caracterizadas encontr\u00e1ndose tanto por homolog\u00eda como por ensayos funcionales que en su mayor\u00eda son antioxidantes perteneciendo a un sistema de defensa del par\u00e1sito contra los productos ros (especies reactivas de ox\u00edgeno) generados por la respuesta inmune del hospedador.  se han caracterizado las siguentes prote\u00ednas: una tiorredoxina peroxidasa(tpx) perteneciente a un grupo de peroxirredoxinas con propiedades antioxidantes; una tiorredoxina(trx) que adem\u00e1s de ser antioxidante es quiz\u00e1s la donadora de los electrones necesarios para la reducci\u00f3n de la tpx haci\u00e9ndola as\u00ed activa y una prote\u00edna disulfuro isomerasa(pdi) que adem\u00e1s de facilitar el plegamiento de prote\u00ednas mediante el establecimiento de enlaces disulfuro act\u00faa como donador de electrones, actuando as\u00ed tambi\u00e9n como antioxidante. a diferencia de otras tpx descritas, la de f. Hepatica no es espec\u00edfica a grupos tioles, sino que tambi\u00e9n protege de la inactivaci\u00f3n usando ascorbato, lo cual sugiere diferencias funcionales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abidentificaci\u00f3n y caracterizaci\u00f3n funcional de prote\u00ednas antioxidantes en el extracto excretor-secretor de fasciola hepatica\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abidentificaci\u00f3n y caracterizaci\u00f3n funcional de prote\u00ednas antioxidantes en el extracto excretor-secretor de fasciola hepatica\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Salazar Calderon M. Elisa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Parra Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Suarez rendueles M\u00aa paz <\/li>\n<li>pablo D\u00edez ba\u00f1os (vocal)<\/li>\n<li>Francisco Antonio Rojo vazquez (vocal)<\/li>\n<li>Fernando Vazquez valdes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Salazar Calderon M. Elisa Mediante el uso de sueros de conejos inmunizados con el extracto excretor-secretor de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,35,8846,661,17,226],"tags":[64695,3216,9512,3215,182879,55744],"class_list":["post-87355","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-oviedo","category-parasitologia-animal","category-quimica","category-zoologia","tag-fernando-vazquez-valdes","tag-francisco-antonio-rojo-vazquez","tag-francisco-parra-fernandez","tag-pablo-diez-banos","tag-salazar-calderon-m-elisa","tag-suarez-rendueles-ma-paz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87355"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87355\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87355"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}