{"id":87368,"date":"2018-03-10T00:12:09","date_gmt":"2018-03-10T00:12:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-famacologica-de-los-autorreceptores-y-meterorreceptores-que-controlan-la-sintesis-de-monoaminas-en-cerebro-de-rata-in-vivo\/"},"modified":"2018-03-10T00:12:09","modified_gmt":"2018-03-10T00:12:09","slug":"modulacion-famacologica-de-los-autorreceptores-y-meterorreceptores-que-controlan-la-sintesis-de-monoaminas-en-cerebro-de-rata-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/modulacion-famacologica-de-los-autorreceptores-y-meterorreceptores-que-controlan-la-sintesis-de-monoaminas-en-cerebro-de-rata-in-vivo\/","title":{"rendered":"Modulacion famacologica de los autorreceptores  y meterorreceptores que controlan la sintesis de monoaminas en cerebro de rata in vivo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Sastre Coll <\/strong><\/h2>\n<p>En el sistema nervioso central, los receptores presin\u00e1pticos modulan la actividad neuronal, s\u00edntesisi y liberaci\u00f3n de neurotransmisor, mediante mecanismos de retroalimentaci\u00f3n negativa mediados por el propio neurotransmisor. estudios cl\u00ednicos y experimentales sugieren la modulaci\u00f3n de estos recptores como un mecasnimo fisiol\u00f3gico que tiende a contrarrestr los cambios en la actividad neuronal. La actividadde los sistemas monoamin\u00e9rgicos est\u00e1 alterada en la depresi\u00f3n end\u00f3gena as\u00ed como en la dicci\u00f3na opi\u00e1ceos. En este sentido existen evidencas experimentales que ponen de manifiesto una sobre-expresi\u00f3n de adrenoceptores a2 y receptores seroton\u00e9rgicos en la depresi\u00f3nend\u00f3gena, as\u00ed como una disminuci\u00f3n en la densidad de estos receptores tras tratamiento con f\u00e1macos antidepresivos. Cambios en la densidad de adrenoceptores a2, pero no de recptores seroton\u00e9rgicos, han sido descritos tambi\u00e9n en la adicci\u00f3n a opi\u00e1ceos. Dado que los receptores presin\u00e1pticos que controlan la s\u00edntsis de monoaminas han sido pocos estudiados y que las rutas de s\u00ednteisi est\u00e1n implicadas en ambos proceos, se consider\u00f3 interesante estudiar la modulaci\u00f3n in vivo de los receptores presin\u00e1pticos que modulan la actividad de los enzimas limitantes de la s\u00ednteisis de monoaminas, durante el tratamiento con f\u00e1rmacos antidepresivos y opi\u00e1ceos en el sistema nervios central. El estudio revela una modulaci\u00f3n dual dependiente del tiempo de los recptores presin\u00e1pticos centrales que modulan la s\u00edntesisi de noradrenalina y serotonina por f\u00e1rmacos antidpresivos in vivo.Los efectos aguados provocados por los f\u00e1rmacos antidepresivos sobre la s\u00edntesisi de monoaminas son opuestos a los cr\u00f3nicos, produci\u00e9ndose una activaci\u00f3n del recptor tras el tratamiento agudo y una posterior desensibilizaci\u00f3n tras el tratamiento cr\u00f3nico. Por otra parte, se encontr\u00f3 un aumento de la inmunoreactividad de la tirosina hidroxilasa en la cortez progrontal de sujetos depri<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion famacologica de los autorreceptores  y meterorreceptores que controlan la sintesis de monoaminas en cerebro de rata in vivo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion famacologica de los autorreceptores  y meterorreceptores que controlan la sintesis de monoaminas en cerebro de rata in vivo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Sastre Coll <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Illes balears<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Andres Garcia Sevilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luisa Ugedo urruela <\/li>\n<li>pablo vicente Escrib\u00e1 ruiz (vocal)<\/li>\n<li>Javier Miralles socias (vocal)<\/li>\n<li>rub\u00e9n v. Rial planas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Sastre Coll En el sistema nervioso central, los receptores presin\u00e1pticos modulan la actividad neuronal, s\u00edntesisi y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,957,817,19034,1408],"tags":[182900,182901,13467,13466,66276,1380],"class_list":["post-87368","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-farmacologia","category-fisiologia-humana","category-illes-balears","category-psiquiatria","tag-antonio-sastre-coll","tag-javier-miralles-socias","tag-jesus-andres-garcia-sevilla","tag-luisa-ugedo-urruela","tag-pablo-vicente-escriba-ruiz","tag-ruben-v-rial-planas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87368"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87368\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}