{"id":87380,"date":"2018-03-10T00:12:09","date_gmt":"2018-03-10T00:12:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-del-fenomeno-lag-en-la-fase-inicial-de-la-isquemia-miocardica-experimental\/"},"modified":"2018-03-10T00:12:09","modified_gmt":"2018-03-10T00:12:09","slug":"estudio-farmacologico-del-fenomeno-lag-en-la-fase-inicial-de-la-isquemia-miocardica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-del-fenomeno-lag-en-la-fase-inicial-de-la-isquemia-miocardica-experimental\/","title":{"rendered":"Estudio farmacol\u00f3gico del fen\u00f3meno \u00ablag\u00bb en la fase inicial de la isquemia mioc\u00e1rdica experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Rodriguez Perez <\/strong><\/h2>\n<p>La disminuci\u00f3n de la contracci\u00f3n ocurre entre los 6 y 10 segundos a partir del comienzo de la isquemia mioc\u00e1rdica. Paralelo a esta ca\u00edda de tensi\u00f3n desarrollada ocurre la disminuci\u00f3n de la m\u00e1xima velocidad de relajaci\u00f3n(-dt\/dtmax). por el contrario, la m\u00e1xima velocidad de contracci\u00f3n(+dt\/dt max) se mantiene durante aproximadamente 1 minuto de isquema global. Este hecho, conocido como fen\u00f3meno \u00ablag\u00bb, fue descrito inicialmente por shine (1976). El mecanismo involucrado en el mantenimiento de este efecto permanenece desconocido, siendo su estudio el objetivo global de esta tesis.  en primer lugar, descartamos que este fen\u00f3meno estuviera ligado a la mera disminuci\u00f3n de la td inducida por cualquier otra maniobra inotr\u00f3pica negativa.  por otra parte, es bien conocida la importante funci\u00f3n que juega el ret\u00edculo sarcopl\u00e1smico(rs) en los fen\u00f3menos de contracci\u00f3n y relajaci\u00f3n mioc\u00e1rdica, por que nuestro trabajo se ha centrado en relacionar la funcionalidad del rs con dicho efecto. Para ello, utilizamos diversas herramientas farmacol\u00f3gicas para inhibir la ga2+-atpasa del rs(\u00e1cido ciclopiaz\u00f3nico) \u00f3 para bloquear los canales de calcio del rs(ryanodina). Dado que el da\u00f1o isqu\u00e9mico mioc\u00e1rdico es consecuencia de la anoxia,(y secundariamente de inhibici\u00f3n metab\u00f3lica) y del ac\u00famulo de catabolitos, estudiamos la contribuci\u00f3n relativa de estos procesos mediante: la caracterizaci\u00f3n del fen\u00f3meno \u00ablag\u00bb durante la hipoxia, el bloqueo de la glicolisis, de la creatina cinasa y de la fosforilizaci\u00f3n oxidativa.  en base a los resultados obtenidos en esta tesis, concluimos que la p\u00e9rdida de la tensi\u00f3n desarrollada inducida por la isquemia mioc\u00e1rdica se ajusta a una funci\u00f3n biexponencial, despareciendo un 20% en una fase inicial de ca\u00edda r\u00e1pida y un 80% en una fase m\u00e1s lenta. Dicha fase r\u00e1pida es independiente de: la funcionalidad del ret\u00edculo sarcopl\u00e1smico, de variaciones de la concentraci\u00f3n del calcio en el l\u00edquido de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacol\u00f3gico del fen\u00f3meno \u00ablag\u00bb en la fase inicial de la isquemia mioc\u00e1rdica experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacol\u00f3gico del fen\u00f3meno \u00ablag\u00bb en la fase inicial de la isquemia mioc\u00e1rdica experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Rodriguez Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santos Barrigon Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fern\u00e1ndez <\/li>\n<li>Jos\u00e9 Mar\u00eda Calleja suarez (vocal)<\/li>\n<li>carmen Delgado canencia (vocal)<\/li>\n<li>Luis Bravo d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Rodriguez Perez La disminuci\u00f3n de la contracci\u00f3n ocurre entre los 6 y 10 segundos a partir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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