{"id":87398,"date":"2018-03-10T00:12:12","date_gmt":"2018-03-10T00:12:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/procesamiento-proteolitico-limitado-por-accion-del-proteasoma-20s\/"},"modified":"2018-03-10T00:12:12","modified_gmt":"2018-03-10T00:12:12","slug":"procesamiento-proteolitico-limitado-por-accion-del-proteasoma-20s","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/procesamiento-proteolitico-limitado-por-accion-del-proteasoma-20s\/","title":{"rendered":"Procesamiento proteolitico limitado por acci\u00f3n del proteasoma 20s"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia-susana Rodr\u00edguez-vilari\u00f1o Poza <\/strong><\/h2>\n<p>El proteasoma es la principal proteasa extralisosomal responsable de la mayor parte de la proteolisis celular, tanto dependiente como independiente de ubiquitinilaci\u00f3n. El proteasoma 20s es un heterolig\u00f3mero, alfa7beta7beta7alfa7, con estructura de cilindro compuesto de cuatro anillo. Habitualmente el proteasoma produce la degradaci\u00f3n total de prote\u00ednas sustrato a oligop\u00e9ptidos. este trabajo se centra en la caracterizaci\u00f3n de la actividad proteol\u00edtica limitada del proteasoma 20s. Esta actividad se manifiesta en el procesamiento de los precursores de las subunidades beta del proteasoma. Este procesamiento ocurre en cis para las subunidades pro-beta activas y en trans para las pro-beta inactivas. Hemos demostrado que la subunidades beta pro-c5 (inactiva) se sintetiza libre en la c\u00e9lula y su procesamiento est\u00e1 acoplado al proceso de ensamblaje en el complejo del proteasoma, no existiendo pro-c5 asociada a precursores de proteasomas. Hemos caracterizado una nueva actividad del proteasoma, el autoprocesamiento por una reacci\u00f3n intermolecular entre proteasomas (procesamiento limitado post-ensamblaje) del extremo c-terminal de la subunidad alfa c2 inducido por la prote\u00edna b\u00e1sica de la mielina. finalmente, hemos identificado un nuevo sustrato que sufre proteolisis limitada en lugar de degradaci\u00f3n, la prote\u00edna tirosina quinasa p60c-src. esta tirosina quinasa es procesada por el proteasoma en su extremo n-terminal, produciendo una disminuci\u00f3n de la actividad quinasa y una perdida de la regi\u00f3n necesaria para su localizaci\u00f3n en membranas. El hecho de que la variante oncog\u00e9nica, v-src, no sea procesada por el proteasoma sugiere que esta prote\u00f3lisis diferencial puede ser un mecanismo adicional que contribuye a la transformaci\u00f3n celular por src.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Procesamiento proteolitico limitado por acci\u00f3n del proteasoma 20s<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Procesamiento proteolitico limitado por acci\u00f3n del proteasoma 20s <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia-susana Rodr\u00edguez-vilari\u00f1o Poza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Gonz\u00e1lez Casta\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Sillero repullo <\/li>\n<li> Sandoval rodr\u00edguez ignacio vicente (vocal)<\/li>\n<li>Jaime Gomez marquez (vocal)<\/li>\n<li>M\u00aa josefa Toro nozal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia-susana Rodr\u00edguez-vilari\u00f1o Poza El proteasoma es la principal proteasa extralisosomal responsable de la mayor parte de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160,115,35,17],"tags":[7151,21180,29709,14322,182944,182943],"class_list":["post-87398","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-quimica","tag-antonio-sillero-repullo","tag-jaime-gomez-marquez","tag-jose-gonzalez-castano","tag-ma-josefa-toro-nozal","tag-sandoval-rodriguez-ignacio-vicente","tag-sonia-susana-rodriguez-vilarino-poza"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87398"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87398\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}