{"id":87399,"date":"2018-03-10T00:12:12","date_gmt":"2018-03-10T00:12:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-proteina-hbx-del-virus-de-la-hepatitis-b-en-los-procesos-inflamatorios-y-la-progresion-tumoral\/"},"modified":"2018-03-10T00:12:12","modified_gmt":"2018-03-10T00:12:12","slug":"implicacion-de-la-proteina-hbx-del-virus-de-la-hepatitis-b-en-los-procesos-inflamatorios-y-la-progresion-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/implicacion-de-la-proteina-hbx-del-virus-de-la-hepatitis-b-en-los-procesos-inflamatorios-y-la-progresion-tumoral\/","title":{"rendered":"Implicacion de la proteina hbx del virus de la hepatitis b en los procesos inflamatorios y la progresion tumoral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Lara Pezzi <\/strong><\/h2>\n<p>La infecci\u00f3n cr\u00f3nica del h\u00edgado por el virus de la hepatitis b est\u00e1 estrechamente relacionada con el desarrollo del hepatocarcinoma. Los mecanismos responsables de la transformacion maligna en la infeccion a viral a\u00fan no han sido bien definidos, y se piensa que tanto factores virales como celulares pueden estar implicados en el proceso. Por una parte, la respuesta inmune del h\u00faesped es la responsable de la eliminaci\u00f3n del viurs. Si la acci\u00f3n del sistema inmunol\u00f3gico no es del todo eficaz, la replicacion viral persiste y la enfermedad cronifica. El da\u00f1o hepatico cr\u00f3nico producido por el sistema inmonol\u00f3gico del huesped se convierte en una condici\u00f3n premaligna, debido a que produce un ciclo sin fin de necrosis, inflamaci\u00f3n y regeneraci\u00f3n que favorecen la aparici\u00f3n del hepatocarcinoma. Por otra parte, la proteina viral hbx favorece el desarrollo del carcinoma, mediante la activaci\u00f3n de distintas cascadas de se\u00f1alizaci\u00f3n que dan lugar a la transcripci\u00f3n de distintos genes implicados en la respuesta inmune y la carcinog\u00e9nesis. en este sentido, se describe en este trabajo la capacidad de hbx de inducir la activaci\u00f3n transcripcional del gen de tnfay de activarel factor de transcripci\u00f3n nf-at, que participa en la transcripci\u00f3n de esta y otras citoquinas proinflamatorias. la expresi\u00f3n de estas citoquinas conduce la inhibici\u00f3n parcial de la replicaci\u00f3n viral, favoreciendo as\u00ed la persistencia de la infecci\u00f3n. Adem\u00e1s, hbx es a menudo la \u00fanica proteina viral que se expresa tras el establecimiento del carcioma, sugiriendo que podria desempe\u00f1ar algun papel en los \u00faltimos estadios del desarrollo tumoral. En este trabajo presentamos evidencias que demuestran que hbx interfiere con las uniones inercelulares, produce un reajuste de la expresion, distribucion y activacion de los receptores de adhesion, alterando la adhesi\u00f3n  a la matriz extracelular, e induce un fenotipo migratorio. En conjunto, estos datos sugieren que hbx par<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion de la proteina hbx del virus de la hepatitis b en los procesos inflamatorios y la progresion tumoral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion de la proteina hbx del virus de la hepatitis b en los procesos inflamatorios y la progresion tumoral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Lara Pezzi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Lopez Cabrera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>Juan  Miguel Redondo moya (vocal)<\/li>\n<li>Jes\u00fas Avila de grado (vocal)<\/li>\n<li>eduardo Mu\u00f1oz blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Lara Pezzi La infecci\u00f3n cr\u00f3nica del h\u00edgado por el virus de la hepatitis b est\u00e1 estrechamente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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