{"id":87483,"date":"2018-03-10T00:12:17","date_gmt":"2018-03-10T00:12:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-genetica-y-quimica-de-componentes-de-la-membrana-externa-de-bacterias-gram-negativas\/"},"modified":"2018-03-10T00:12:17","modified_gmt":"2018-03-10T00:12:17","slug":"caracterizacion-genetica-y-quimica-de-componentes-de-la-membrana-externa-de-bacterias-gram-negativas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-genetica-y-quimica-de-componentes-de-la-membrana-externa-de-bacterias-gram-negativas\/","title":{"rendered":"Caracterizacion genetica y quimica de componentes de la membrana externa de bacterias gram negativas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cesar O. Sanchez Roitz <\/strong><\/h2>\n<p>1. Identificaci\u00f3n de un gen\/es de aeromonas hydrophila y de plesiomonas shiglloides implicado en la bios\u00edntesis del lps:  los resultados obtenidos nos ha permitido caracterizar geneticamente un gen de aeromonas hydrophila que, expresado en escherichia coli, confiere resistencia a la bacteriocina 28b. En este trabajo hemos descrito la posibilidad de utilizar la bacteriocina 28b para identificar genes implicados en la bios\u00edntesis del lps, concretamente del l\u00edpido a, en aeromonas hydrophila.  el gen caracterizado, denominado waan, codifica para una aciltransferasa que interviene en el paso de acilaci\u00f3n final en la biosintesis del lipido a. Especificamente se trata de una miristoiltransferasa.  la mutaci\u00f3n del gen waan de aeromonas hydrophila, la primera que se realiza en pasos de la biosintesis del lipido a en este genero, provoca una disminuci\u00f3n de los niveles de \u00e1cido miristico unido al l\u00edpido a, sin afectar los niveles de acido l\u00e1urico. As\u00ed mismo hemos observado que el gen waan no es esencial para el crecimiento. Su mutaci\u00f3n provoca cambios en la velocidad de crecimiento, as\u00ed como cambios morfol\u00f3gicos importantes de las colonias y a nivel celular.  caracter\u00edsticas muy similares a las descritas posee el gen waan de pleiomonas shigelloides, cuya similitud nucleot\u00eddica con el gen waan de aeromonas hydrophila es tambi\u00e9n muy alta. La mutaci\u00f3n del mismo tampoco es esencial para el crecimiento, y confiere a la cepa caracteristicas fenotipicas similares al mutante ah3 waan. Estos cambios fen\u00f3tipicos pueden deberse a modificaciones en la fluidez de la membrana, asi como alteraciones en la pared celular. uno de los aspectos m\u00e1s interesantes de los mutantes est\u00e1 relacionado con la p\u00e9rdida de virulencia. Los mutantes ah3 waan y ps302 waan muestran una disminucion en su capacidad de invasividad y adherencia muy marcada, asi como diferencias en otros aspectos relacionados con la patogenocidad como la sensibilidad al suero y al c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion genetica y quimica de componentes de la membrana externa de bacterias gram negativas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion genetica y quimica de componentes de la membrana externa de bacterias gram negativas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cesar O. Sanchez Roitz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Regu\u00e9 Queralt<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Guinea s\u00e1nchez <\/li>\n<li>jordi Barb\u00e9 Garc\u00eda (vocal)<\/li>\n<li>joan Tom\u00e1s i maga\u00f1a (vocal)<\/li>\n<li>vicente j. Benedi benito (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cesar O. Sanchez Roitz 1. Identificaci\u00f3n de un gen\/es de aeromonas hydrophila y de plesiomonas shiglloides implicado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1418,951,35,278],"tags":[183084,283,19952,14152,19951,172262],"class_list":["post-87483","post","type-post","status-publish","format-standard","hentry","category-bacteriologia","category-barcelona","category-ciencias-de-la-vida","category-microbiologia","tag-cesar-o-sanchez-roitz","tag-jesus-guinea-sanchez","tag-joan-tomas-i-magana","tag-jordi-barbe-garcia","tag-miguel-regue-queralt","tag-vicente-j-benedi-benito"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=87483"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/87483\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=87483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=87483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=87483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}