{"id":87511,"date":"2018-03-10T00:12:21","date_gmt":"2018-03-10T00:12:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-indicadores-clinicos-y-biologicos-en-tumores-cerebrales-utilidad-de-la-recogida-prospectiva-de-materal-tumoral\/"},"modified":"2018-03-10T00:12:21","modified_gmt":"2018-03-10T00:12:21","slug":"valor-pronostico-de-indicadores-clinicos-y-biologicos-en-tumores-cerebrales-utilidad-de-la-recogida-prospectiva-de-materal-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-indicadores-clinicos-y-biologicos-en-tumores-cerebrales-utilidad-de-la-recogida-prospectiva-de-materal-tumoral\/","title":{"rendered":"Valor pronostico de indicadores clinicos y biologicos en tumores cerebrales. utilidad de la recogida prospectiva de materal tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> I\u00f1igo Cristobal Pomposo Gaztelu <\/strong><\/h2>\n<p>Se procedi\u00f3 a la recogida prospectiva de material tumoral, excedente para las necesidades de diagn\u00f3stico histol\u00f3gico, en los quir\u00f3fanos del servicio de neurocirug\u00eda del hospital de cruces y de otros centros p\u00fablicos y privados de la red sanitaria del pa\u00eds vasco. La recogida comenz\u00f3 en el a\u00f1o 1991 y se prolong\u00f3 hasta 1998, con un total de 392 muestras recopiladas. adem\u00e1s, se obtuvo la informacion cl\u00ednica detallada de cada caso tras dise\u00f1ar una base de datos que permit\u00eda la recuperaci\u00f3n \u00e1gil de esta informaci\u00f3n.  este material tumoral junto a la informaci\u00f3n cl\u00ednica propici\u00f3 la creaci\u00f3n y desarrollo de un banco de turmores del snc. Se realizaron numerosas determinaciones de comportamiento biol\u00f3gico tumoral, mediante el estudio de proliferaci\u00f3n celular (pcna, ki67), y otros marcadores biol\u00f3gicos (vegf, p53). Posteriormente se han analizado estad\u00edsticamente la correlaci\u00f3n entre estos marcadores tumorales y los factores cl\u00ednicos, con el objetivo de establecer el valor pron\u00f3stico de estas determinaciones, especialmente en cu\u00e1nto a la supervivencia en astrocitomas y a la recurrencia en meningiomas.En t\u00e9rminos de supervivencia, en los primeros, se ha encontrado correlaci\u00f3n estad\u00edsticamente significativa con indicadores comunes a todos los tipos histol\u00f3gicos como es la edad, el porcentaje de c\u00e9lulas tumorales que presentan imunopositividad nuclear para el pcna y los \u00edndices de inmunomarcado con el ki67. En t\u00e9rminos de recidiva en los meningiomas se ha encotrado correlaci\u00f3n estad\u00edsticamente significativa con indicadores cl\u00ednicos, como son el tama\u00f1o tumoral, la extensi\u00f3n de la ex\u00e9resis quir\u00fargica y el grado histol\u00f3gico; y con indicadores de proliferaci\u00f3n celular, como son el procentaje de c\u00e9lulas en fase s. determinando por citometr\u00eda de flujo y el porcentaje de c\u00e9lulas inmunopositivas para el pcna.  al estudiar el vegf es astrocitomas, observamos una supervivencia signficativamente m\u00e1s prolongada en a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pronostico de indicadores clinicos y biologicos en tumores cerebrales. utilidad de la recogida prospectiva de materal tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pronostico de indicadores clinicos y biologicos en tumores cerebrales. utilidad de la recogida prospectiva de materal tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 I\u00f1igo Cristobal Pomposo Gaztelu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garibir Undarrena Jes\u00fas M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Do\u00f1ate oliver <\/li>\n<li>Jaime Mendez martin (vocal)<\/li>\n<li>f\u00e9lix Cruz s\u00e1nchez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de I\u00f1igo Cristobal Pomposo Gaztelu Se procedi\u00f3 a la recogida prospectiva de material tumoral, excedente para las necesidades [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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