{"id":87566,"date":"2018-03-10T00:12:21","date_gmt":"2018-03-10T00:12:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ha%c2%adbridos-peptidos-oligonucleotido-con-aminoacidos-oxidables-sa%c2%adntesis-estudio-estructural-e-interaccion-con-el-anticancera%c2%adgeno-cisplatino\/"},"modified":"2018-03-10T00:12:21","modified_gmt":"2018-03-10T00:12:21","slug":"ha%c2%adbridos-peptidos-oligonucleotido-con-aminoacidos-oxidables-sa%c2%adntesis-estudio-estructural-e-interaccion-con-el-anticancera%c2%adgeno-cisplatino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/ha%c2%adbridos-peptidos-oligonucleotido-con-aminoacidos-oxidables-sa%c2%adntesis-estudio-estructural-e-interaccion-con-el-anticancera%c2%adgeno-cisplatino\/","title":{"rendered":"H\u00edbridos p\u00e9ptidos-oligonucle\u00f3tido con amino\u00e1cidos oxidables: s\u00edntesis, estudio estructural e interacci\u00f3n con el anticancer\u00edgeno cisplatino"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente March\u00e1n Sancho <\/strong><\/h2>\n<p>Utilizando una estrategia lineal en fase s\u00f3lida se han sintetizado nucleop\u00e9ptidos, conjugados p\u00e9ptido-oligonocle\u00f3tido con una uni\u00f3n fosfato-di\u00e9ster, que incorporan los amino\u00e1cidos oxidables tript\u00f3fano, metionina y ciste\u00edna. Tambi\u00e9n se han preparado una serie de conjugados p\u00e9ptido-oligonucle\u00f3tido para llevar a cabo estudios de complejaci\u00f3n con compuestos de platino (ii).  el estudio estructural mediante t\u00e9cnicas de resonancia magn\u00e9tica nuclear bidimensionales del d\u00faplex formado por un nucleop\u00e9ptido, que contiene unresiduo de tript\u00f3fano, con su cadena oligonucleot\u00eddica complementaria, ha mostrado que la cadena lateral de este amino\u00e1cido se apila sobre una guanina terminal en lugar de intercalarse entre pares de bases. Dicha interacci\u00f3n hidrof\u00f3fica comporta una estabilizaci\u00f3n adicional del d\u00faplex de dna. Asimismo, los estudios mediante curvas de fusi\u00f3n han revelado que un p\u00e9ptido unido covalentemente a un d\u00faplex de dna ejerce un efecto estabilizante.  finalmente, los estudios de complejaci\u00f3n con el anticancer\u00edgeno cisplatino han mostrado la preferente formaci\u00f3n de aductos tricoordinados en los que el platino coordina simult\u00e1neamente dos amino\u00e1cidos, histidina y metionina en nuestro caso, y una guanina. La formaci\u00f3n de estos productos se explica por la gran afinidad de los compuestos de platino (ii) por la cadena lateral de la metionina, as\u00ed como tambi\u00e9n por la p\u00e9rdida del ligando amon\u00edaco trans al tio\u00e9ter en este amino\u00e1cido, lo cual permite la introducci\u00f3n de un tercer ligando en la esfera de coordinaci\u00f3n del metal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>H\u00edbridos p\u00e9ptidos-oligonucle\u00f3tido con amino\u00e1cidos oxidables: s\u00edntesis, estudio estructural e interacci\u00f3n con el anticancer\u00edgeno cisplatino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 H\u00edbridos p\u00e9ptidos-oligonucle\u00f3tido con amino\u00e1cidos oxidables: s\u00edntesis, estudio estructural e interacci\u00f3n con el anticancer\u00edgeno cisplatino <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente March\u00e1n Sancho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Grandas Sagarra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jaume Villarrasa llorens <\/li>\n<li>angel Garc\u00eda raso (vocal)<\/li>\n<li>federico Gago bardenas (vocal)<\/li>\n<li>pilar Gonzalez duarte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente March\u00e1n Sancho Utilizando una estrategia lineal en fase s\u00f3lida se han sintetizado nucleop\u00e9ptidos, conjugados p\u00e9ptido-oligonocle\u00f3tido con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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