{"id":87574,"date":"2018-03-10T00:12:25","date_gmt":"2018-03-10T00:12:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-de-los-nucleotidos-de-guanina-con-los-receptores-ionotropicos-de-glutamato\/"},"modified":"2018-03-10T00:12:25","modified_gmt":"2018-03-10T00:12:25","slug":"interaccion-de-los-nucleotidos-de-guanina-con-los-receptores-ionotropicos-de-glutamato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/interaccion-de-los-nucleotidos-de-guanina-con-los-receptores-ionotropicos-de-glutamato\/","title":{"rendered":"Interaccion de los nucleotidos de guanina con los receptores ionotropicos de glutamato."},"content":{"rendered":"<h2>Tesis doctoral de <strong> JavierSantos Burgos Mu\u00f1oz <\/strong><\/h2>\n<p>Los receptores de amino\u00e1cidos excitatorios son los principales receptores implicados en la excitaci\u00f3n sinaptica del sistema nervioso central de los vertebrados. El objetivo de este trabajo fue la demostraci\u00f3n de la capacidad inhibitoria de los nucle\u00f3tidos de guanina (ng), en sus vertientes como desplazantes, antagonistas y neuroprotectores, de los efectos causados por la interacci\u00f3n de los aminoacidos excitatorios con los receptores ionotropicos de glutamato.  el abordaje teorico y experimental se realiz\u00f3 considerando tres niveles de experimentacion, analisis de resultados y discusion de los mismos: en primer lugar, confirmamos la afinidad de los ng por el sitio de reconocimiento de agonistas y antagonistas competitivos radiactivos en los receptores de glutamato, en el modelo de retina de pollo, a continuaci\u00f3n, analizamos en car\u00e1cter antagonista de los ng sobre las acciones mediadas por los agonistas de glutamato, mediante dos sitemas experimentales: la evocaci\u00f3n de respuestas el\u00e9ctricas en ovocitos de xnopus trasplantados con membranas de retina de polli, y la estimulacion del flujo de 45ca2+ por diversos agonistas e glutamato en explantes de retina, por ultimo, analizamos el comportamiento neuroprotector de los ng sobre diferentes agresiones exitotoxicas causadas por la hiperactivacion de los receptores de glutamato, para ello, y en el modelo de explantes de retina de pollo, estudiamos la destruccion celular, mediante detecci\u00f3n de la liberacion del enzima intracelular lactato deshidrogenasa, causada tanto por la adicion de agonistas como por la ausencia de calcio. el efecto neuroprotector de algunos ng fue corroborado por y mediante el uso de un modelo de epilepsia causado por administraci\u00f3n intracerebroventricular de un agonista del receptor de nmda, el \u00e1cido quinolinico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion de los nucleotidos de guanina con los receptores ionotropicos de glutamato.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion de los nucleotidos de guanina con los receptores ionotropicos de glutamato. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 JavierSantos Burgos Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Galo Ramirez Ortiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cecilio Gimenez martin <\/li>\n<li>jorgina Satr\u00fastegui gil-delgado (vocal)<\/li>\n<li>jordi Marsal teb\u00e9 (vocal)<\/li>\n<li>Manuel Ros perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de JavierSantos Burgos Mu\u00f1oz Los receptores de amino\u00e1cidos excitatorios son los principales receptores implicados en la excitaci\u00f3n sinaptica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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