{"id":87631,"date":"2018-03-10T00:12:29","date_gmt":"2018-03-10T00:12:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-farmacodinamia-del-netotrexato-en-pacientes-oncologicos-pediatricos\/"},"modified":"2018-03-10T00:12:29","modified_gmt":"2018-03-10T00:12:29","slug":"farmacocinetica-y-farmacodinamia-del-netotrexato-en-pacientes-oncologicos-pediatricos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-y-farmacodinamia-del-netotrexato-en-pacientes-oncologicos-pediatricos\/","title":{"rendered":"Farmacocin\u00e9tica y farmacodinamia del netotrexato en pacientes oncol\u00f3gicos pedi\u00e1tricos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene Aquerrta Gonz\u00e1lez <\/strong><\/h2>\n<p>Objetivos  caracterizar la disposici\u00f3n del metotrexato (mtx) en la poblaci\u00f3n de pacientes de oncolog\u00eda pedi\u00e1trica a partir de la informaci\u00f3n adquirida en la monitorizaci\u00f3n cl\u00ednica diaria de manera que pueda ser aplicado a un programa de predicci\u00f3n posol\u00f3gica basado en m\u00e9todos bayesianos.  pacientes y m\u00e9todos  los par\u00e1metros farmacocin\u00e9ticos del mtx tando individuales como poblacionales se estimaron en 310 ciclos de tratamiento de 56 pacientes empleando un m\u00e9todo param\u00e9trico de dos etapas (it2b, iterative two-stage bayesian) y uno no param\u00e9trico de una etapa (npem, nonparametric expectation maximization). los par\u00e1metros farmacocin\u00e9ticos obtenidos se validaron en otra poblaci\u00f3n de 30 pacientes mediante bayesiano a posteriori. Se analiz\u00f3 la relaci\u00f3n entre las variables cualitativas y cuantitativas de inter\u00e9s con los par\u00e1metros farmacocin\u00e9ticos del tx mediante regresi\u00f3n m\u00faltiple. Para el estudio de las relaciones farmacocin\u00e9ticas-farmacodin\u00e1micas del mtx en t\u00e9rminos de toxicidad hematol\u00f3gica, agastrointestinal y renal, se emple\u00f3 la refresi\u00f3n m\u00faltiple y la regresi\u00f3n log\u00edstica. El estudio de las relaciones farmacocin\u00e9ticas-farmacodin\u00e1micas del mtx en t\u00e9rminos de eficacia, definiendo la respuesta cl\u00ednica al mtx como supervivencia libre de enfermedad hasta progresi\u00f3n  (sle) y tiempo de supervivencia del paciente, se llev\u00f3 a cabo mediante regresi\u00f3n de cox. se estimaron los tiempos \u00f3ptimos de muestreo del mtx mediante el programa sample module para su aplicaci\u00f3n cl\u00ednica psoterior.  resultados y conclusi\u00f3n  los par\u00e1metros farmacocin\u00e9ticos poblacionales obtendios mediante it2b fueron los siguientes, media (desviaci\u00f3n est\u00e1ndar):kel 0,2829 (0,0460)h-1; kcp 0,0022 (0,0013)h-1;kpc 0,0291 (0,0166)h-1; vs 0,4774 (0,2091) l\/kg y los obtenidos mediante npem: kel 0,3144 (0,0728)h-1; kcp 0,0051 (0,0035)h-1; kpc 0,0536 (0,0307)h-1; vs 0,4799 (0,2555) l\/kg. Estos par\u00e1metros predijeron correctamente las conc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica y farmacodinamia del netotrexato en pacientes oncol\u00f3gicos pedi\u00e1tricos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica y farmacodinamia del netotrexato en pacientes oncol\u00f3gicos pedi\u00e1tricos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene Aquerrta Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2000<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Azucena Aldaz Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>victor Jimenez torres (vocal)<\/li>\n<li>Jos\u00e9 Luis Vila jato (vocal)<\/li>\n<li>Luis Sierrasesumaga arisnavarreta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene Aquerrta Gonz\u00e1lez Objetivos caracterizar la disposici\u00f3n del metotrexato (mtx) en la poblaci\u00f3n de pacientes de oncolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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